Table 3.
Baseline characteristics of 176 migraine patient, separated by the presence of interictal widespread hyperalgesia (left) and acute allodynia (right)
| Migraine without IWH | Migraine with IWH | p value | Migraine without ACA | Migraine with ACA | p value | |
|---|---|---|---|---|---|---|
| n = 102 | n = 74 | n = 61 | n = 115 | |||
| Variables | ||||||
| General variables | ||||||
| Female gender | 80 (78.4%) | 68 (91.9%) | 0.027 x | 45 (73.8%) | 103 (89.6%) | 0.012 x |
| Age (years) | 39.9 ± 9.7 | 37.4 ± 10.6 | 0.106t | 39.4 ± 11.0 | 38.5 ± 9.7 | 0.595t |
| Migraine-specific variables | ||||||
| Migraine type | 0.703x | 0.038 x | ||||
| Migraine without aura | 62 (60.8%) | 42 (56.8%) | 43 (70.5%) | 61 (53.0%) | ||
| Migraine with aura | 40 (39.2%) | 32 (43.2%) | 18 (29.5%) | 54 (47.0%) | ||
| Age at migraine onset (years) | ||||||
| less than 15 | 18 (17.6%) | 22 (29.7%) | 0.043 x | 13 (21.3%) | 27 (23.5%) | 0.032 x |
| 15-19 | 26 (25.5%) | 20 (27.0%) | 9 (14.8%) | 37 (32.2%) | ||
| 20-24 | 17 (16.7%) | 12 (16.2%) | 9 (14.8%) | 20 (17.4%) | ||
| 25-29 | 7 (6.9%) | 9 (12.2%) | 8 (13.1%) | 8 (7.0%) | ||
| 30 or more | 34 (33.3%) | 11 (14.9%) | 22 (36.1%) | 23 (20.0%) | ||
| Migraine duration (years) | ||||||
| less than10 | 27 (26.5%) | 15 (20.3%) | 0.351x | 22 (36.1%) | 20 (17.4%) | 0.027 x |
| 10-19 | 35 (34.3%) | 33 (44.6%) | 18 (29.5%) | 50 (43.5%) | ||
| 20-29 | 27 (26.5%) | 14 (18.9%) | 15 (24.6%) | 26 (22.6%) | ||
| 30 or more | 13 (12.7%) | 12 (16.2%) | 6 (9.8%) | 19 (16.5%) | ||
| Duration of headache attack (hours) | 0.884x | 0.456x | ||||
| 12 or less | 46 (45.1%) | 35 (47.3%) | 30 (49.2%) | 51 (44.3%) | ||
| 13-24 | 40 (39.2%) | 25 (33.8%) | 24 (39.3%) | 41 (35.7%) | ||
| 25-48 | 9 (8.8%) | 8 (10.8%) | 3 (4.9%) | 14 (12.2%) | ||
| more than 48 | 7 (6.9%) | 6 (8.1%) | 4 (6.6%) | 9 (7.8%) | ||
| Frequency of headache (no/year) | 0.005 x | 0.011 x | ||||
| 1-6 | 23 (22.5%) | 6 (8.1%) | 16 (26.2%) | 13 (11.3%) | ||
| 7-12 | 20 (19.6%) | 11 (14.9%) | 11 (18.0%) | 20 (17.4%) | ||
| 13-54 | 51 (50.0%) | 40 (54.1%) | 31 (50.8%) | 60 (52.2%) | ||
| more than 54 | 8 (7.8%) | 17 (23.0%) | 3 (4.9%) | 22 (19.1%) | ||
| Headache intensity | 0.621f | 0.486f | ||||
| Mild | 4 (3.9%) | 1 (1.4%) | 2 (3.3%) | 3 (2.6%) | ||
| Moderate | 40 (39.2%) | 28 (37.8%) | 27 (44.3%) | 41 (35.7%) | ||
| Severe | 58 (56.9%) | 45 (60.8%) | 32 (52.5%) | 71 (61.7%) | ||
| Headache disability (HIT-6) | 0.056x | 0.004 x | ||||
| severe (60 or more) | 56 (54.9%) | 52 (70.3%) | 28 (5.9%) | 80 (69.6%) | ||
| Acute cutaneous allodynia (yes) | 59 (57.8%) | 56 (75.7%) | 0.022 x | – | – | |
| Interictal WPH (yes) | – | – | 18 (29.5%) | 56 (48.7%) | 0.022 x | |
| Migraine-associated symptoms | ||||||
| Nausea/Vomiting | 96 (94.1%) | 69 (93.2%) | 1f | 58 (95.1%) | 107 (93.0%) | 0.75 f |
| Photophobia | 76 (74.5%) | 62 (83.8%) | 0.197x | 37 (60.7%) | 101 (87.8%) | <0.001 x |
| Phonophobia | 62 (60.8%) | 56 (75.7%) | 0.056x | 27 (44.3%) | 91 (79.1%) | <0.001 x |
| Osmophobia | 44 (43.1%) | 37 (50.0%) | 0.454x | 21 (34.4%) | 60 (52.2%) | 0.037 x |
| Depression (SDS48 or more) | 15 (14.7%) | 23 (31.1%) | 0.016 x | 10 (16.4%) | 28 (24.3%) | 0.304x |
| Use of medication | ||||||
| Use of acute medication | 14 (13.7%) | 13 (17.6%) | 0.627x | 9 (14.8%) | 18 (15.7%) | 1x |
| Use of a triptan | 45 (44.1%) | 33 (44.6%) | 1x | 22 (36.1%) | 56 (48.7%) | 0.148x |
| Use of prophylactic drugs | 6 (5.9%) | 11 (14.9%) | 0.083x | 4 (6.6%) | 13 (11.3%) | 0.455x |
Values are absolute numbers with corresponding % or means ±SD
p-values depicted in bold italic indicate significant difference (p < 0.05)
IWH interictal widespread hyperalgesia, ACA acute cutaneous allodynia, HIT-6 headache impact test, SDS self-rating depression scale
xχ2 test
fFisher’s exact test
tt-test