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. 2017 Oct 30;6(4):37. doi: 10.3390/biology6040037

Figure 1.

Figure 1

The activator RNA unit (P5abc RNA) and the core ribozyme module (ΔP5 RNA) were used to form a bimolecular group I ribozyme and engineered group I ribozymes for the assembly of RNA nanostructures. (A) Secondary structures of P5abc RNA and its variants used in this study. (B) ΔP5 RNA corresponding to the core structure of the Tetrahymena group I ribozyme. (C) Partial structure of Lα RNA and Lβ RNA showing the modular organization of the ΔP5 module and P5abc module, which are connected at P8 and P5a via a duplex linker. (D) Partial structure of F RNA showing the modular organization of the ΔP5 module that presents the R(C-loop) motif and the P5abc module with the C-loop motif. The two modules are connected at P5 and P5b via a duplex linker. In F RNA, the original 5′ and 3′ ends of the C-loop P5abc RNA (see Figure 1A) were capped with a stable 5′-UUCG-3′ tetraloop.