Table 1.

Role of oxidative stress-related EVs on cell viability and tissue inflammation.

Cell/Tissue Type of Origin	EV Type	Oxidative Stress Condition	Oxidative Stress-Related Cargo	Effect	Reference
Cardiomyocytes	Exosomes	Ethanol, hypoxia/reoxy-genation	HSP60	TLR4-mediated apoptosis	Heiserman et al. [67]
Mast cells	Exosomes	H2O2	mRNA	H2O2 tolerance	Eldh et al. [68]
Retinal pigment epithelial cells	Exosomes	Ethanol	VEGF protein and mRNA	Angiogenesis	Atienzar-Aroca et al. [69]
HEK293 cells	Exosomes + MVs	Ca2+ ionophore (Lipoxygenase stimulator)	Oxidized phospholipids	TLR4-mediated NFκB activation	Mancek-Keber et al. [70]
Liver	MVs	High fat diet treated mice (NASH model)	Oxidized mtDNA	TLR9-induced TNFα, IL-6 production	Garcia-Martinez et al. [71]
Liver	MVs	Chronic-plus-binge alcohol drinking	mtDNA	TLR9-mediated neutrophilic inflammation	Cai et al. [72]
Liver	Exosomes	Alcoholic hepatitis	miR-122	Sensitize monocytes to LPS	Momen-Heravi et al. [73]
Liver	MVs	Saturated fatty acid-induced lipotoxicity	TRAIL	DR5-dependent macrophage activation	Hirsova et al. [74]
Macrophage	Exosomes	Myocardial infarction	miR-155	Fibroblast inflammation	Wang et al. [75]
Cardiosphere-derived cells	EVs	Myocardial infarction	Y RNA fragment	IL-10 expression and secretion	Cambier et al. [76]