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MnP treatment lowered serum adipokines. (A) serum insulin; (B) serum leptin and (C) serum PAI-1 were measured at 5, 10, and 12 weeks of HFD feeding, n = 5 mice per group. Data are displayed as mean ± SEM. Significance was calculated by two-way ANOVA with a Bonferroni post-test of multiple comparisons. * indicates p ≤ 0.05, ** indicates p ≤ 0.01 and *** indicates p ≤ 0.001.
