Table 2.
Membrane polyunsaturated fatty acid concentration (µg/mg protein, mean ± SD) in the prefrontal cortex, cerebellum, striatum, and hippocampus of adult rhesus macaques (n = 9).
| Region | Nuclear | Myelin | Neuronal | Mitochondrial | |
|---|---|---|---|---|---|
| Prefrontal Cortex | Arachidonic Acid | 123.5 ± 30.0 a | 99.3 ± 30.5 b | 96.44 ± 20.0 b | 28.0 ± 16.3 c |
| PUFA n-6 | 291.7 ± 77.5 a | 204.9 ± 48.9 b | 201.6 ± 63.5 b | 49.2 ± 27.6 c | |
| Docosahexaenoic acid | 151.9 ± 37.2 a | 180.6 ± 48.9 a | 175.8 ± 54.8 a | 35.3 ± 19.2 b | |
| PUFA n-3 | 164.2 ± 44.6 a | 187.6 ± 51.7 a | 182.9 ± 56.8 a | 36.2 ± 19.8 b | |
| Total PUFA | 455.9 ± 120.6 a | 392.4 ± 99.9 a | 384.5 ± 120.1 a | 85.4 ± 47.1 b | |
| Cerebellum | Arachidonic Acid | 91.4 ± 19.1 a | 84.4 ± 32.8 a | 95.9 ± 20.4 a | 15.1 ± 5.8 b |
| PUFAn-6 | 213.0 ± 40.2 a | 166.1 ± 59.3 b | 187.6 ± 38.0 a,b | 30.3 ± 11.4 c | |
| Docosahexaenoic acid | 136.0 ± 26.5 a | 178.2 ± 59.9 b | 199.8 ± 39.7 b | 27.8 ± 10.2 c | |
| PUFA n-3 | 148.8 ± 30.0 a | 185.9 ± 63.3 b | 207.3 ± 40.9 b | 28.7 ± 10.5 c | |
| Total PUFA | 361.8 ± 69.4 a | 352.0 ± 121.4 a | 394.9 ± 76.7 a | 59.0 ± 21.9 b | |
| Striatum | Arachidonic Acid | 221.5 ± 65.4 a | 156.2 ± 20.5 b | 143.9 ± 26.5 b | 30.5 ± 13.3 c |
| PUFA n-6 | 525.2 ± 177.7 a | 315.5 ± 46.4 b | 289.0 ± 47.6 b | 52.9 ± 22.1 c | |
| Docosahexaenoic acid | 196.9 ± 36.1 a | 257.7 ± 35.0 b | 201.0 ± 37.2 a | 37.3 ± 17.4 c | |
| PUFA n-3 | 224.0 ± 43.9 a | 268.7 ± 36.7 b | 211.7 ± 38.5 a | 38.4 ± 17.8 c | |
| Total PUFA | 749.2 ± 217.5 a | 584.2 ± 81.6 b | 500.7 ± 85.1 c | 91.4 ± 39.6 d | |
| Hippocampus | Arachidonic Acid | 208.0 ± 54.6 a,b | 247.1 ± 119.7 a | 170.6 ± 50.4 b | 21.6 ± 6.6 c |
| PUFA n-6 | 452.0 ± 126.0 a | 519.7 ± 226.7 a | 340.0 ± 104.9 b | 37.0 ± 10.9 c | |
| Docosahexaenoic acid | 144.2 ± 40.9 a | 325.2 ± 118.7 b | 201.5 ± 63.4 c | 16.7 ± 5.5 d | |
| PUFA n-3 | 191.6 ± 54.2 a | 347.7 ± 127.5 b | 219.4 ± 69.7 a | 18.2 ± 5.5 c | |
| Total PUFA | 643.6 ± 177.5 a,b | 867.5 ± 351.2 a | 559.5 ± 173.8 b | 55.2 ± 16.1 c |
Means with different superscripts (a, b, c, d) in each row are significantly different, according to one-way analysis of variance (ANOVA) followed by Tukey’s honest significance difference (HSD) test (p < 0.05). PUFA: polyunsaturated fatty acids.