Figure 3.

BuOE but not GC4403 prevents indications of mitochondrial dysfunction after repetitive compressive loading. (A) Mitochondrial stress test-derived basal and maximum oxygen consumption rates of chondrocytes extracted from the loaded portions of healthy 0.25 MPa loaded explants and injurious 1.0 MPa loaded explants with or without GC4403 or BuOE (n = 4). (B) Proton leak by extracted chondrocytes as a percentage of the basal activity by each sample (n = 4). (C) Overall mean fluorescence intensity of confocal images taken of cross sections of loaded portions of each explant staining with MitoTracker Deep Red (n = 4). * indicate p < 0.01 compared to 0.25 MPa loading and ** indicate p < 0.01 compared to 1 MPa loading without treatment.