Table 1.
The Correlation between Clinicopathologic Characteristics and FEN1 IHC Staining in NSCLC
| Variable∗ | FEN1 IHC score, n (%) |
P value | |||
|---|---|---|---|---|---|
| − | + | ++ | +++ | ||
| Age group, years | |||||
| ≤60 | 24 (28) | 4 (29) | 3 (18) | 7 (39) | 0.5777 |
| >60 | 63 (72) | 10 (71) | 14 (82) | 11 (61) | |
| Sex | |||||
| Male | 27 (31) | 8 (57) | 6 (35) | 10 (56) | 0.0939 |
| Female | 60 (69) | 6 (43) | 11 (65) | 8 (44) | |
| Tobacco history | |||||
| Never used | 16 (25) | 0 (0) | 1 (8) | 1 (7) | 0.1603 |
| Previous used | 13 (20) | 0 (0) | 4 (33) | 4 (27) | |
| Current used | 36 (55) | 7 (100) | 7 (58) | 10 (67) | |
| Histology | |||||
| Adenocarcinoma | 81 (94) | 13 (93) | 16 (94) | 16 (89) | 0.6708 |
| SCC | 1 (1) | 1 (7) | 0 (0) | 1 (6) | |
| Adenosquamous | 4 (5) | 0 (0) | 1 (6) | 1 (6) | |
| Differentiation | |||||
| Well differentiated | 22 (27) | 2 (14) | 0 (0) | 0 (0) | 0.0120 |
| Moderately differentiated | 35 (43) | 4 (29) | 8 (47) | 12 (67) | |
| Poorly differentiated | 25 (30) | 8 (57) | 9 (53) | 6 (33) | |
| Node status | |||||
| Node negative | 28 (64) | 3 (75) | 3 (60) | 7 (100) | 0.2686 |
| Node positive | 16 (36) | 1 (25) | 2 (40) | 0 (0) | |
| Recurrence | |||||
| No | 62 (74) | 11 (85) | 10 (59) | 15 (88) | 0.2002 |
| Yes | 22 (26) | 2 (15) | 7 (41) | 2 (12) | |
| Ki-67 average | |||||
| Negative <1% | 49 (59) | 8 (57) | 5 (29) | 4 (22) | 0.0006 |
| Moderate 1%–<5% | 22 (27) | 3 (21) | 5 (29) | 1 (6) | |
| High 5%–25% | 9 (11) | 2 (14) | 5 (29) | 9 (50) | |
| Higher >25% | 3 (4) | 1 (7) | 2 (12) | 4 (22) | |
−, <1%; +, 1% to <5%; ++, 5% to 25%; +++, >25%; IHC, immunohistochemistry; SCC, squamous cell carcinoma.
∗
Pearson χ2 test.