Table 3.

Associations with the occurrence of CRC (univariate, multivariate conditional logistic regression and after 1000 bootstrapped multivariate conditional logistic regressions) for clinical covariates

Covariates	Model	Univariatea			Multivariateb			Bootstrapped multivariate analysisb			% of bootstrap selection
		HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
Living	Rural / Mix vs. Urban	2.82	1.96–4.06	p < 0.0001	2.50	1.48–4.23	p = 0.0006	2.26	1.36–3.75	0.0015	87
Job	Rural / Mix vs. Urban	3.44	2.24–5.29	p < 0.0001	2.99	1.63–5.48	p = 0.0004	2.93	1.61–5.34	0.0004	87
Red meat consumption	≥3 portions/week vs. <3	1.63	1.01–2.63	p = 0.0458							45
Tobacco consumption	Tobacco exposure <30 years vs. never	0.86	0.60–1.25	p = 0.4290	1.17	0.70–1.95	0.5439	1.13	0.69–1.84	0.6235	73
	Tobacco exposure ≥30 years vs. never	1.82	1.10–3.03	p = 0.0207	3.37	1.63–6.96	0.0010	2.73	1.39–5.39	0.0036
Alcohol consumption	> 30 g/day now or in the past vs. ≤ 30 g/day	2.62	1.49–4.59	p = 0.0008	1.06	0.50–2.22	0.8725				26
	Never vs. ≤ 30 g/day	2.75	1.77–4.27	p < 0.0001	3.05	1.69–5.50	0.0002
Physical activity	<30 vs. ≥ 30 min/day	5.83	3.74–9.07	p < 0.0001	6.35	3.70–10.9	p < 0.0001	6.73	4.07–11.14	p < 0.0001	100

^acrude values, ^badjusted values