Table 2.
In vitro interaction of cryptolepine combinations against 3D7 P. falciparum strains
| Drug combination | ΣFIC50 | Mean ΣFIC50 | Interaction | |||
|---|---|---|---|---|---|---|
| 4:1 | 3:2 | 2:3 | 1:4 | |||
| Cryptolepine + amodiaquine | 0.640 ± 0.08 | 0.0234 ± 0.11 | 0.0631 ± 0.07 | 0.421 ± 0.12 | 0.287 ± 0.10 | Synergism |
| Cryptolepine + mefloquine | 3.015 ± 0.91 | 3.013 ± 1.01 | 5.106 ± 1.13 | 5.595 ± 0.91 | 4.182 ± 0.99 | Antagonism |
| Cryptolepine + lumefantrine | 2.1108 ± 0.17 | 1.6865 ± 0.01 | 0.1475 ± 0.02 | 0.1245 ± 0.04 | 1.017 ± 0.06 | Additivity |
| Cryptolepine + chloroquine | 1.95 ± 0.21 | 1.775 ± 0.36 | 1.66 ± 0.04 | 0.475 ± 0.05 | 1.465 ± 0.17 | Additivity |
The ratios 4:1, 3:2, 2:3 and 1:4 refer to fixed dosage ratios for drug A (cryptolepine) to drug B (amodiaquine, mefloquine, lumefantrine, chloroquine). Values are the means from ≥ 3 experiments