Table 1.
Blood pressure effect of angiotensin II from entire cohort
| Author (year) | Cases Total/+data | Type of shock | SBP ↑ (mmHg) | MAP ↑ (mmHg) | Dose range Median (IQR) |
||
|---|---|---|---|---|---|---|---|
| Septic | Other | Cardiogenic | |||||
| Del Greco (1961) [25] | 20/20 | 7 | 11 | 2 | 47.4 | 0.23–100 mcg/min 2.5 mcg/min (13.5) |
|
| Nassif (1963) [34] | 14/13 | 6 | 6 | 2 | 106.9 | 7–1500 mcg bolus 14 mcg/min (32) |
|
| Wedeen (1963) [35] | 15/7 | 1 | 3 | 11 | 81.1 | 1.5–36 mcg/min 10 mcg/min (6.5) |
|
| Beanlands (1964) [36] | 17/0 | 0 | 0 | 17 | a | 1–36 mcg/min 2 mcg/min (2.25) |
|
| Udhoji (1964) [26] | 12/6 | 4 | 5 | 3 | 34.3 | b | |
| Belle (1965) [37] | 1/1 | 0 | 0 | 1 | 16.0 | 50–250 mg/day - - |
|
| Cohn (1965) [27] | 6/6 | 6 | 0 | 0 | 29.7 | b | |
| Cohn (1965) [27] | 22/22 | 0 | 22 | 0 | 22.1 | 0.3–60 mcg/min 14.1 mcg/min - |
|
| Singh (1966) [28] | 25/0 | 25 | 0 | 0 | c | 4–12 mcg/min - - |
|
| Wallace (1967) [29] | 7/7 | 0 | 7 | 0 | 22.9 | 0.75- mcg/min 1.5 mcg/min (0) |
|
| Sorensen (1986) [32] | 8/0 | 0 | 8 | 0 | d | b | |
| Moore (1989) [33] | 9/0 | 0 | 9 | 0 | e | 2.9 ng/kg/min - - |
|
| Geary (1990) [38] | 1/1 | 0 | 0 | 1 | 30.0 | 6 mcg/min - - |
|
| Thacker (1990) | 2/2 | 0 | 2 | 0 | 27.5 | 6–7 mcg/min 6.5 mcg/min - |
|
| Thomas (1991) [40] | 1/0 | 1 | 0 | 0 | f | 5–20 mcg/min 10 mcg/min - |
|
| Jackson (1993) [20] | 1/0 | 0 | 1 | 0 | g | 3–18 mcg/min 18 mcg/min - |
|
| Trilli (1994) [21] | 1/1 | 0 | 0 | 1 | 24.0 | 8.5–9 mcg/min 8.5 mcg/min - |
|
| Ryding (1995) [41] | 1/1 | 1 | 0 | 0 | 18.0 | 3.5–4.2 mcg/min - - |
|
| Newby (1995) [22] | 1/1 | 0 | 1 | 0 | 30.0 | 0.8–2.2 mcg/min 22 ng/kg/min - |
|
| Wray (1995) [24] | 1/0 | 1 | 0 | 0 | h | 8–22 mcg/min 8 mcg/min - |
|
| Tovar (1997) [23] | 1/1 | 0 | 1 | 0 | 50.0 | 5–15 mcg/min 15 mcg/min - |
|
| Eyraud (1998) [30] | 14/14 | 0 | 14 | 0 | 74.0 | 2.5 mcg bolus - - |
|
| Chawla (2014) [10] | 10/10 | 10 | 0 | 0 | 6.0 | 15–20 ng/kg/min 20 ng/kg/min - |
|
| Khanna (2017) [11] | 163/163 | 163 | 0 | 0 | 12.5 | 20–40 ng/kg/min 2.8 mg (5.8) |
|
| Total | 353/276 | 225 | 90 | 38 | 71.3i | 14.8i | |
SBP systolic blood pressure, MAP mean arterial pressure, IQR interquartile range (in units similar to that study’s dose range)
aFrom 52.8 mmHg to > 100 mmHg in 13 of 18 patients
bData unavailable
cFrom < 90 mmHg to > 90 mmHg
dFrom BP of 76/48 mmHg to DBP of > 68 mmHg
e20 mmHg increase from average SBP of 81.7 mmHg
fFrom 52 mmHg to > 100 mmHg
gFrom 50 mmHg to > 100 mmHg
hFrom < 80 mmHg to > 80 mmHg
iWeighted average