Figure 2.

Study design and data preprocessing. A, Study design. B, Venn diagram showing miRNAs commonly expressed between the three studies included in the meta-analysis. C, Statistical heterogeneity estimation. I² scores of commonly expressed miRNAs (n = 176) in epileptogenesis and in chronic stage. miRNAs are ordered based on the adjusted p value after meta-analysis. I² < 0.3, low heterogeneity; 0.3 < I² > 0.7, moderate heterogeneity; I² > 0.7, high heterogeneity. SRS, spontaneous recurrent seizures; pilo, pilocarpine model; amy stim, amygdala stimulation model; AB stim, angular bundle stimulation model.