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. 2017 Dec 28;4(6):ENEURO.0152-17.2017. doi: 10.1523/ENEURO.0152-17.2017

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Copyright © 2017 Srivastava et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Relationship between selected miRNA and their predicted targets in different model of TLE. All panels show selected miRNAs-mRNA anticorrelation based on miRNAs and mRNAs fold changes in epileptogenesis. A, Inverse relationship between four downregulated miRNAs (miR-92b-3p, miR-101a-3p, miR-153-3p, and miR-3573-3p) and the commonly predicted target Map3k4. B, Inverse relationship between the downregulated miR-138-5p, miR-7a-5p, and the upregulated Map3k14. C, Inverse relationship between miR-101a-3p, miR-139-3p, miR-551b-3p, and Syn2. D, Inverse relationship between miR-150-5p, miR-383-5p, and Ptpn. E, F, Examples of the opposite anticorrelation, the upregulated miR-146a-5p with the downregulated Htr5b transcript, and the upregulated miR-212-5p and the downregulated Gabrd transcript.