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. 2017 Dec 28;4(6):ENEURO.0152-17.2017. doi: 10.1523/ENEURO.0152-17.2017

Table 6.

miRNA-mRNA fold changes positive correlation in epileptogenesis

miRNA Name microRNA data
 mRNA targets of respective microRNA (FDR < 0.1)
Pilocarpine Perforant path stimulation Amygdala stimulation mRNA gene names Pilocarpine
 Perforant path stimulation
 Amygdala stimulation
 Kainic acid
miRNA FC Meta-analysis p value FC Adjusted p value FC Adjusted p value FC Adjusted p value FC Adjusted p value
miR-383-5p -0.50 -0.35 -0.75 6.11−05 Rasd2 -0.58 0.0038 -1.24 0.0012 -0.59 0.0010 -0.87 0.0034
Sec14l1 -0.59 0.0061 -0.50 0.0425 -0.39 0.0053 -0.20 0.0726
Mpp6 -0.59 0.0295 -0.54 0.0517 -0.39 0.4123 -0.78 0.0510
miR-153-3p -0.32 -0.42 -0.22 0.0008 Mthfd1l -1.27 0.0398 -0.83 0.0102 -0.94 0.0005 -0.44 0.0093
Gdf10 -2.91 8.62−06 -1.46 0.0306 -1.86 2.27−07 -1.02 0.0014
Nr4a3 0.12 0.9726 -1.65 0.0721 -1.64 0.0574 -0.65 0.0042
Mettl7a -0.74 0.0066 -0.72 0.0861 -0.87 0.0750 -0.19 0.0500
Ablim2 -0.05 0.9953 -0.78 0.0964 -0.35 0.7323 -0.29 0.0667
miR-324-5p -0.09 -0.60 -0.29 8.552−06 Ryr1 -1.52 0.0022 -1.39 0.0196 -1.86 2.53−08 -0.68 0.0014
miR-150-5p -0.45 -0.45 -0.56 6.168−05 Ddit4l -2.38 0.0063 -1.89 0.0098 -2.00 6.09−06 -1.09 0.0007
Htr5b -1.55 3.87−05 -1.66 0.0263 -0.54 0.0096 -0.73 0.0016
Fkbp4 -0.21 0.7718 -0.55 0.0464 -0.45 0.0737 -0.26 0.0775
Pip5k1b -1.03 0.0228 -0.46 0.0492 -0.79 0.1731 -0.38 0.0619
Calml4 -0.60 0.3155 -0.44 0.0839 -0.48 0.1135 -0.38 0.0139
miR-92b-3p -1.05 -0.72 -0.37 1.695−05 Per2 -0.59 0.8691 -0.46 0.0717 -0.56 0.0253 -0.37 0.0918
miR-345-5p -0.23 -0.25 -0.12 1.464−06 Rasd2 -0.58 0.0038 -1.24 0.0012 -0.59 0.0010 -0.87 0.0034
Ryr1 -1.52 0.0022 -1.39 0.0196 -1.86 2.53−08 -0.68 0.0014
Klhl14 -2.36 2.39−06 -1.66 0.0204 -0.84 0.0006 -0.44 0.0077
B3galt5 -1.93 0.0118 -0.83 0.0442 -1.39 7.49−05 -0.43 0.0471
Pip5k1b -1.03 0.0228 -0.46 0.0492 -0.79 0.1731 -0.38 0.0619
Rspo3 -0.41 0.5671 -0.41 0.0626 -0.11 0.1711 -0.55 0.0259
Fat1 -1.55 0.0012 -1.01 0.0717 -1.05 0.0012 -0.19 0.0792
miR-101a-3p -0.68 -0.71 -0.19 5.148−06 Rasd2 -0.58 0.0038 -1.24 0.0012 -0.59 0.0010 -0.87 0.0034
Ddit4l -2.38 0.0063 -1.89 0.0098 -2.00 6.09−06 -1.09 0.0007
Gdf10 -2.91 8.62−06 -1.46 0.0306 -1.86 2.27−07 -1.02 0.0014
Plk5 -2.15 0.0033 -0.59 0.0311 -1.46 0.0013 -1.00 0.0303
Plag1 -0.58 0.0528 -0.45 0.0425 0.06 0.5075 -0.59 0.0453
miR-29c-5p -0.59 -0.41 -0.14 1.477−07 Crim1 -1.07 0.0084 -0.59 0.0173 -0.87 9.88−06 -0.31 0.0323
Dnah12 -0.35 0.9054 0.65 0.0492 0.32 0.4073 0.22 0.0340
C5ar1 0.43 0.2817 0.33 0.3103 0.44 0.0181 0.24 0.0841
Slc20a1 0.27 0.0883 0.14 0.5191 0.41 0.0227 0.45 0.0042
miR-330-3p -0.99 -0.40 -0.32 1.935−06 Gabrd -0.71 0.0282 -0.59 0.0067 -0.53 0.0053 -0.55 0.0070
Ets2 -0.44 0.3991 -0.66 0.0249 -0.44 0.0641 -0.31 0.0095
Gpc3 -1.92 0.0026 -0.85 0.0492 -0.89 0.0006 -1.29 0.0054
miR-138-5p -0.48 -0.29 -0.50 3.983−08 Rasd2 -0.58 0.0038 -1.24 0.0012 -0.59 0.0010 -0.87 0.0034
Nr4a1 0.24 0.7205 -0.88 0.0125 -0.56 0.4123 -0.32 0.0719
Crim1 -1.07 0.0084 -0.59 0.0173 -0.87 9.88−06 -0.31 0.0323
Nhlh1 -1.67 0.0023 -1.12 0.0337 -0.63 0.0295 -0.84 0.0097
Nr4a3 0.12 0.9726 -1.65 0.0721 -1.64 0.0574 -0.65 0.0042
miR-667-3p -0.34 -0.20 -0.49 1.62−07 Rasd2 -0.58 0.0038 -1.24 0.0012 -0.59 0.0010 -0.87 0.0034
Etv5 -0.08 0.9646 -0.63 0.0423 -0.47 0.2965 -0.49 0.0044
miR-212-5p 2.55 0.27 0.28 1.152−05 Sox11 1.52 0.0027 1.36 0.0092 1.57 0.0063 1.23 0.0011
Serping1 1.15 0.1500 1.22 0.0204 1.19 0.0034 2.12 0.0009
Map3k14 0.20 0.8682 0.77 0.0263 0.11 0.0834 0.26 0.0653
Ptprn 0.83 0.0001 0.56 0.0613 0.38 0.0034 0.33 0.0648
Kank2 0.00 0.9473 0.71 0.0673 0.62 0.0153 0.59 0.0241
Acan 0.30 0.0723 0.37 0.0799 0.17 0.2577 0.37 0.0436
Slc7a14 0.35 0.1717 0.42 0.0877 0.91 0.0003 0.23 0.0568
C1qc 0.92 0.1759 0.42 0.3397 1.11 0.0014 0.97 0.0816
Ly86 0.58 0.0494 0.40 0.4124 0.87 0.0299 0.97 0.0299
Slc20a1 0.27 0.0883 0.14 0.5191 0.41 0.0227 0.45 0.0042
Blnk 0.70 0.0039 0.43 0.1925 0.71 0.0377 0.78 0.0158
Bdnf 1.17 0.0297 0.20 0.6933 0.45 0.0352 0.32 0.0487
Pdlim4 0.19 0.7034 0.15 0.5799 0.15 0.0771 0.46 0.0721
Syn2 0.39 0.0258 0.55 0.0299 0.65 0.0399 0.11 0.2134
Epb41l4b 0.57 0.0030 0.58 0.0237 0.70 0.0008 0.17 0.4555
Nnat 0.63 0.2970 0.86 0.0717 1.09 0.0083 0.15 0.5894
Htatip2 0.79 0.0007 0.37 0.0669 0.70 0.0119 -0.02 0.9557
Trh 2.87 0.0096 1.31 0.0246 1.20 0.0145 0.99 0.3361
Asph 0.05 0.9026 0.45 0.0254 0.45 0.0832 0.17 0.1308
let-7b-3p -0.80 -0.41 -5.75 8.364−06 Rspo3 -0.41 0.5671 -0.41 0.0626 -0.11 0.1711 -0.55 0.0259
miR-132-3p 1.91 0.80 0.10 4.195−18 Efr3a 1.11 4.17−07 1.40 0.0005 1.28 0.0096 0.49 0.0070
Sox11 1.52 0.0027 1.36 0.0092 1.57 0.0063 1.23 0.0011
Wls 1.75 1.52−05 0.80 0.0108 1.45 7.49−05 0.57 0.0051
Rin2 -0.06 0.9546 0.43 0.0517 0.57 0.0638 0.44 0.0303
Gpnmb 0.81 0.2150 0.30 0.6840 1.54 0.0030 1.45 0.0259
Zfp521 0.59 0.0031 0.74 0.0052 1.23 0.0002 0.23 0.2169
Asph 0.05 0.9026 0.45 0.0254 0.45 0.0832 0.17 0.1308
miR-146a-5p 4.71 0.37 0.33 4.047−10 Mdm1 0.29 0.0680 0.76 0.0027 0.69 0.0360 0.30 0.0322
Inpp4b 0.24 0.1291 1.15 0.0027 0.80 0.1003 0.31 0.0735
Arhgap17 0.33 0.0762 0.88 0.0080 0.30 0.0183 0.43 0.0259
Igsf1 0.50 0.4934 0.89 0.0425 1.03 0.3719 0.31 0.0510
Gpat3 0.44 0.4497 0.40 0.0864 -0.04 0.2317 0.16 0.0923
Sowahc 0.53 0.0683 0.45 0.3070 1.09 0.0006 0.28 0.0873
Fcer1g 1.09 0.0112 0.51 0.1380 1.14 0.0002 1.37 0.0059
Slfn13 0.40 0.1166 0.41 0.1757 0.46 0.0429 1.53 0.0027
Zfp521 0.59 0.0031 0.74 0.0052 1.23 0.0002 0.23 0.2169
Anks1a 0.17 0.5280 0.53 0.0492 0.72 0.0323 0.28 0.1948
Trh 2.87 0.0096 1.31 0.0246 1.20 0.0145 0.99 0.3361
Ntm -0.32 0.9428 0.37 0.0861 0.71 0.0527 -0.22 0.3746
Col9a1 1.28 0.0003 0.91 0.0425 0.41 0.0208 0.03 0.9192
miR-551b-3p -0.78 -0.85 -0.42 9.092−14 Plxdc1 -0.70 0.0007 -0.73 0.0127 -0.28 0.0555 -0.33 0.0823
Ogfrl1 -0.23 0.1736 -0.52 0.0135 -0.55 0.0293 -0.30 0.0563
Htr5b -1.55 3.87−05 -1.66 0.0263 -0.54 0.0096 -0.73 0.0016
Diaph1 -0.27 0.2293 -0.30 0.0492 0.07 0.3960 -0.23 0.0530
miR-344b-2-3p 3.74 0.11 0.29 5.432−14 Runx1 1.22 0.0009 1.48 0.0027 1.08 0.0008 0.60 0.0027
Il18 0.31 0.3608 0.52 0.0669 0.38 0.1009 0.51 0.0955
Chi3l1 0.33 0.8228 0.02 0.9731 1.14 0.0881 0.31 0.0785
Fancd2os 0.85 0.0043 0.36 0.1786 0.66 0.0353 0.28 0.0372
P2ry6 0.50 0.1614 0.12 0.7169 0.17 0.0499 0.61 0.0231
Asph 0.05 0.9026 0.45 0.0254 0.45 0.0832 0.17 0.1308
miR-139-5p -1.40 -0.77 -0.91 4.4−17 Gabrd -0.71 0.0282 -0.59 0.0067 -0.53 0.0053 -0.55 0.0070
Gdf10 -2.91 8.62−06 -1.46 0.0306 -1.86 2.27−07 -1.02 0.0014
Rspo3 -0.41 0.5671 -0.41 0.0626 -0.11 0.1711 -0.55 0.0259
miR-33-5p -2.40 -0.80 -0.51 4.916−19 Smarca2 -0.60 0.2192 -1.53 0.0186 -0.35 0.0904 -0.27 0.0340
Fxyd7 -1.49 7.16−05 -1.65 0.0186 -0.98 0.0052 -0.30 0.0142
Arg1 -1.24 0.0324 -0.49 0.0984 -0.37 0.0679 -0.50 0.0344
miR-7a-5p -0.91 -0.93 -0.51 3.436−24 Hpca -0.40 0.0880 -0.64 0.0090 -0.74 0.0220 -0.22 0.0244
miR-212-3p 1.09 0.88 0.22 1.744−47 Efr3a 1.11 4.17−07 1.40 0.0005 1.28 0.0096 0.49 0.0070
Sox11 1.52 0.0027 1.36 0.0092 1.57 0.0063 1.23 0.0011
Wls 1.75 1.52−05 0.80 0.0108 1.45 7.49−05 0.57 0.0051
Rin2 -0.06 0.9546 0.43 0.0517 0.57 0.0638 0.44 0.0303
Gpnmb 0.81 0.2150 0.30 0.6840 1.54 0.0030 1.45 0.0259
Zfp521 0.59 0.0031 0.74 0.0052 1.23 0.0002 0.23 0.2169
Asph 0.05 0.9026 0.45 0.0254 0.45 0.0832 0.17 0.1308