Table 8.
GO and KEGG enrichment of 122 predicted and anticorrelated mRNAs targets of 22 miRNAs differentially expressed in epileptogenesis
| GO terms | Term description | GO ID | Size of term | miRNA target | Expected | Enrichment ratio | Raw p value | FDR |
|---|---|---|---|---|---|---|---|---|
| Biological process | Single-organism process | GO:004469 | C = 2489 | O = 67 | E = 42.21 | R = 1.59 | 6.29−08 | 5.71−05 |
| Biological process | Complement activation | GO:000695 | C = 11 | O = 5 | E = 0.19 | R = 26.80 | 5.34−07 | 0.0002 |
| Biological process | Protein activation cascade | GO:007237 | C = 13 | O = 5 | E = 0.22 | R = 22.68 | 1.45−06 | 0.0004 |
| Biological process | Humoral immune response | GO:000695 | C = 16 | O = 5 | E = 0.27 | R = 18.43 | 4.72−06 | 0.0009 |
| Biological process | Complement activation, classical pathway | GO:000695 | C = 8 | O = 4 | E = 0.14 | R = 29.48 | 5.14−06 | 0.0009 |
| Biological process | B cell-mediated immunity | GO:001972 | C = 32 | O = 6 | E = 0.54 | R = 11.06 | 1.28−05 | 0.0013 |
| Biological process | Regulation of immune system process | GO:000268 | C = 242 | O = 15 | E = 4.10 | R = 3.65 | 1.05−05 | 0.0013 |
| Biological process | Response to stimulus | GO:005089 | C = 2294 | O = 59 | E = 38.90 | R = 1.52 | 1.25−05 | 0.0013 |
| Biological process | Immunoglobulin-mediated immune response | GO:001606 | C = 32 | O = 6 | E = 0.54 | R = 11.06 | 1.28−05 | 0.0013 |
| Biological process | Humoral immune response mediated by circulating immunoglobulin | GO:000245 | C = 10 | O = 4 | E = 0.17 | R = 23.59 | 1.50−05 | 0.0014 |
| Biological process | Signaling | GO:002305 | C = 1510 | O = 44 | E = 25.61 | R = 1.72 | 2.68−05 | 0.002 |
| Biological process | Single-organism signaling | GO:004470 | C = 1510 | O = 44 | E = 25.61 | R = 1.72 | 2.68−05 | 0.002 |
| Biological process | Signal transduction | GO:000716 | C = 1308 | O = 39 | E = 22.18 | R = 1.76 | 6.75−05 | 0.0047 |
| Biological process | Immune system process | GO:000237 | C = 446 | O = 19 | E = 7.56 | R = 2.51 | 0.0001 | 0.0057 |
| Biological process | Positive regulation of immune response | GO:005077 | C = 90 | O = 8 | E = 1.53 | R = 5.24 | 0.0001 | 0.0057 |
| Biological process | Cellular response to stimulus | GO:005171 | C = 1711 | O = 46 | E = 29.02 | R = 1.59 | 0.0001 | 0.0057 |
| Biological process | Lymphocyte mediated immunity | GO:000244 | C = 51 | O = 6 | E = 0.86 | R = 6.94 | 0.0002 | 0.0086 |
| Biological process | Cell communication | GO:000715 | C = 1570 | O = 43 | E = 26.63 | R = 1.62 | 0.0002 | 0.0086 |
| Biological process | Positive regulation of response to stimulus | GO:004858 | C = 380 | O = 17 | E = 6.44 | R = 2.64 | 0.0002 | 0.0086 |
| Biological process | Regulation of immune response | GO:005077 | C = 125 | O = 9 | E = 2.12 | R = 4.25 | 0.0002 | 0.0086 |
| Biological process | Immune effector process | GO:000225 | C = 120 | O = 9 | E = 2.04 | R = 4.42 | 0.0002 | 0.0086 |
| Biological process | Immune response | GO:000695 | C = 221 | O = 12 | E = 3.75 | R = 3.20 | 0.0003 | 0.0124 |
| Biological process | B cell homeostasis | GO:000178 | C = 9 | O = 3 | E = 0.15 | R = 19.66 | 0.0004 | 0.0151 |
| Biological process | Adaptive immune response based on somatic recombinationof immune receptors built from immunoglobulin superfamily domains | GO:000246 | C = 59 | O = 6 | E = 1.00 | R = 6.00 | 0.0004 | 0.0151 |
| Biological process | Antigen processing and presentation of exogenous peptide antigen | GO:000247 | C = 10 | O = 3 | E = 0.17 | R = 17.69 | 0.0005 | 0.0175 |
| Biological process | Response to lipid | GO:003399 | C = 342 | O = 15 | E = 5.80 | R = 2.59 | 0.0005 | 0.0175 |
| Biological process | Adaptive immune response | GO:000225 | C = 62 | O = 6 | E = 1.05 | R = 5.71 | 0.0006 | 0.0202 |
| Biological process | Negative regulation of mature B cell apoptotic process | GO:000290 | C = 3 | O = 2 | E = 0.05 | R = 39.31 | 0.0008 | 0.0234 |
| Biological process | Mature B cell apoptotic process | GO:000290 | C = 3 | O = 2 | E = 0.05 | R = 39.31 | 0.0008 | 0.0234 |
| Biological process | Regulation of mature B cell apoptotic process | GO:000290 | C = 3 | O = 2 | E = 0.05 | R = 39.31 | 0.0008 | 0.0234 |
| Biological process | Activation of immune response | GO:000225 | C = 66 | O = 6 | E = 1.12 | R = 5.36 | 0.0008 | 0.0234 |
| Biological process | Epidermis development | GO:000854 | C = 92 | O = 7 | E = 1.56 | R = 4.49 | 0.0009 | 0.0255 |
| Biological process | Positive regulation of immune system process | GO:000268 | C = 153 | O = 9 | E = 2.59 | R = 3.47 | 0.001 | 0.0267 |
| Biological process | Innate immune response | GO:004508 | C = 94 | O = 7 | E = 1.59 | R = 4.39 | 0.001 | 0.0267 |
| Biological process | Antigen processing and presentation of peptide antigen | GO:004800 | C = 13 | O = 3 | E = 0.22 | R = 13.61 | 0.0012 | 0.0294 |
| Biological process | Antigen processing and presentation of exogenous antigen | GO:001988 | C = 13 | O = 3 | E = 0.22 | R = 13.61 | 0.0012 | 0.0294 |
| Biological process | Leukocyte mediated immunity | GO:000244 | C = 71 | O = 6 | E = 1.20 | R = 4.98 | 0.0012 | 0.0294 |
| Biological process | Regulation of fibroblast proliferation | GO:004814 | C = 29 | O = 4 | E = 0.49 | R = 8.13 | 0.0013 | 0.0311 |
| Biological process | Multicellular organismal process | GO:003250 | C = 1895 | O = 46 | E = 32.14 | R = 1.43 | 0.0017 | 0.0322 |
| Biological process | Negative regulation of B cell apoptotic process | GO:000290 | C = 4 | O = 2 | E = 0.07 | R = 29.48 | 0.0017 | 0.0322 |
| Molecular function | Molecular transducer activity | GO:006008 | C = 309 | O = 14 | E = 4.99 | R = 2.81 | 0.0004 | 0.029 |
| Molecular function | Signal transducer activity | GO:000487 | C = 309 | O = 14 | E = 4.99 | R = 2.81 | 0.0004 | 0.029 |
| KEGG pathway | Staphylococcus aureus infection | C = 15 | O = 6 | E = 0.21 | R = 28.48 | 2.97−08 | 9.80−07 | |
| KEGG pathway | Complement and coagulation cascades | C = 17 | O = 6 | E = 0.24 | R = 25.13 | 7.19−08 | 1.19−06 | |
| KEGG pathway | Systemic lupus erythematosus | C = 25 | O = 5 | E = 0.35 | R = 14.24 | 2.10−05 | 0.0002 | |
| KEGG pathway | p53 signaling pathway | C = 25 | O = 3 | E = 0.35 | R = 8.55 | 0.0049 | 0.027 | |
| KEGG pathway | Antigen processing and presentation | C = 25 | O = 3 | E = 0.35 | R = 8.55 | 0.0049 | 0.027 | |
| KEGG pathway | Pathways in cancer | C = 142 | O = 7 | E = 1.99 | R = 3.51 | 0.0037 | 0.027 | |
| KEGG pathway | MAPK signaling pathway | C = 123 | O = 6 | E = 1.73 | R = 3.47 | 0.0075 | 0.0354 | |
| KEGG pathway | Pancreatic cancer | C = 34 | O = 3 | E = 0.48 | R = 6.28 | 0.0117 | 0.0429 | |
| KEGG pathway | Colorectal cancer | C = 33 | O = 3 | E = 0.46 | R = 6.47 | 0.0108 | 0.0429 | |
| KEGG pathway | Lysosome | C = 70 | O = 4 | E = 0.98 | R = 4.07 | 0.0165 | 0.0495 | |
| KEGG pathway | Neuroactive ligand-receptor interaction | C = 72 | O = 4 | E = 1.01 | R = 3.96 | 0.0182 | 0.0495 | |
| KEGG pathway | Chronic myeloid leukemia | C = 38 | O = 3 | E = 0.53 | R = 5.62 | 0.0159 | 0.0495 | |
| KEGG pathway | Natural killer cell-mediated cytotoxicity | C = 41 | O = 3 | E = 0.58 | R = 5.21 | 0.0195 | 0.0495 | |