| Faglia et al. ([116]) |
Exercise ECG and dipyridamole-stress echo |
71 |
58.7 ± 8.3 |
46 |
28 |
9 |
4.4 |
21.4 |
In the screened arm, the proportion of all events (P = 0.018) as well as the proportion of major to minor events (P = 0.006) was significantly less |
| No screening |
70 |
61.5±8.1 |
55 |
21 |
12 |
NA |
| DIAD (Young et al. [117]) |
Stress scintigraphy |
561 |
60.7 ± 6.7 |
10 |
37 |
43 |
4.8 |
22 |
No difference in cardiac death or nonfatal MI (HR): 0.88; 95% CI: 0.44–1.88; P = 0.73 |
| No screening |
562 |
60.8 ± 6.4 |
9 |
41 |
46 |
NA |
| DYNAMIT (Lièvre et al. [118]) |
Bicycle exercise test or stress scintigraphy |
316 |
64.1 ± 6.4 |
17 |
33 |
39 |
3.5 |
21.5 |
No difference in composite primary endpoint (death from all causes, nonfatal MI, nonfatal stroke, or heart failure requiring emergency intervention) between the screening and the nonscreening group (2.6% versus 2.4% annually; adjusted HR: 1.0; 95% CI: 0.59–1.71) |
| No screening |
315 |
63.7 ± 6.4 |
14 |
36 |
24 |
NA |
| FACTOR-64 (Muhlestein et al. [119]) |
Coronary CT angiogram (CCTA) |
452 |
61.5 ± 7.9 |
16 |
76 |
43 |
4.0 |
69 |
The primary outcome event rates not significantly different between the CCTA and the control groups (6.2% versus 7.6%; hazard ratio: 0.80 [95% CI: 0.49–1.32]; P = 0.38) |
| No screening |
448 |
61.6 ± 8.3 |
15 |
72 |
40 |
NA |
| DADDY-D (Turrini et al. [120]) |
Exercise ECG |
262 |
61.9 ± 4.8 |
40 |
39 |
29 |
3.6 |
7.6 |
No difference in cardiac events (HR = 0.85, 95% CI: 0.39–1.83, P = 0.678) or occurrence of first HF episode (HR = 0.27, 95% CI: 0.06–1.31, P = 0.083) |
| No screening |
258 |
62 ± 5.1 |
37 |
44 |
25 |
NA |
