Fig. 12.

The interactions between the drugs and Bcl-2(4IEH) in the binding site. Ten random poses of matrine docked into the active site of 4IEH (a).The binding modes of matrine in Bcl-2: at least two residues involved in the interactions in ten random poses, Asn102, Arg105 (h-bonds) (b). Ten random poses of cisplatin docked into the same active site of 4IEH (c). The binding modes of cisplatin in 4IEH: at least eight residues involved in the interactions in ten random poses, Ala59, Asp62, Arg66, Try67, Asp70, Gly104 and Ala108 (h-bonds), and Tyr67, Tyr161 (π–π interaction) (d)