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Effect of matrine and cisplatin alone and in combination on ROS level. The ROS level of EJ (a) and T24 cells (b) treated with 5 mM of matrine, 4 μM of cisplatin alone and 1 μM of cisplatin and 2 mM of matrine in combination for 48 h. Histograms represent the average ROS level of EJ (c) and T24 (d). All data are shown as the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, or ****P < 0.0001 versus the control group
