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. 2017 Dec 28;17:124. doi: 10.1186/s12935-017-0495-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Suppressive effect of matrine, cisplatin and the combination on VEGF/PI3K/Akt signaling pathway in EJ and T24 cells. Figures are the protein expression levels of Bax, Bcl-2, Cleaved Caspase-3, Caspase-3, p-Akt, Akt, p-PI3K, PI3K, VEGFR2, VEGF and GAPDH of EJ and T24 cells treated with 4 μM of cisplatin, 5 mM of matrine and 1 μM of cisplatin and 2 mM of matrine in combination (a, f) for 48 h. Histograms present the relative grey value of the related proteins measured by ImageJ (b–e, g–j). All data are shown as the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, or ****P < 0.0001 versus the control group