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. 2017 Dec 28;17:124. doi: 10.1186/s12935-017-0495-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — The 3D structures of crystal structures of the tested proteins. The 3D crystal structure of human PI3K with an endogenous ligand (PDB-ID: 4J6I) (a), Akt2 with an endogenous ligand (PDB-ID: 2JDR) (b), Caspase-3 with an endogenous ligand (PDB-ID: 2XYH) (c) and Bcl-2 with an endogenous ligand (PDB-ID: 4IEH) (d)