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. 2017 Dec 28;17:124. doi: 10.1186/s12935-017-0495-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — The interactions between the drugs and PI3K(4J6I) in the binding site. Ten random poses of matrine docked into the active site of 4J6I (a). The binding modes of matrine in PI3K: at least one residue involved in the interactions in ten random poses, Lys890 (h-bonds) (b). Ten random poses of cisplatin docked into the same active site of 4J6I (c). The binding modes of cisplatin in PI3K: at least eight residues involved in the interactions in ten random poses, Lys802, Lys833, Asp836, Asp884 Ala885, Lys890 and Asp964 (h-bonds), and Tyr867 (π–π interaction) (d)