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. 2017 Dec 14;2017:8286248. doi: 10.1155/2017/8286248

Figure 7.

Figure 7

IGF-2 knockdown and extracellular IGFBP-6 addition in PMSCs under muscle differentiation conditions decreased the frequency of cells with high ALDH activity. Compared to PMSCs under muscle differentiation conditions (siRNA scrambled control), cells treated with IGF-2 siRNA showed decreased frequency of cells with high ALDH activity at day 1, while adding extracellular IGFP-6 with IGF-2 siRNA showed decreased frequency of cells with high ALDH activity at each time point. Data is presented as the mean ± SEM of 3 independent experiments. Two-way ANOVA with Bonferroni's multiple comparison test was performed to determine ∗∗P < 0.01, and ∗∗∗P < 0.001 compared to scrambled siRNA control, or ###P < 0.001 compared to IGF-2 siRNA.