Table 3.
Clinical and biochemical assessment during follow up
| Mean ± SD | P1* | P2* | P3* | P4* | ||||
|---|---|---|---|---|---|---|---|---|
| Visit ‘0’ (Baseline) Screening | Visit ‘1’ (1 month) CZ 85 mg | Visit ‘2’ (2 months) CZ 250 mg | Visit ‘3’ (3 months) CZ 500 mg | |||||
| Pulse rate (min−1) | 73.4 ± 8.4 | 71.9 ± 9.2 | 71.5 ± 8.4 | 75.8 ± 8.6 | NS | NS | <0.05 | NS |
| Systolic Blood Pressure (mmHg) | 124.0 ± 10.8 | 118.0 ± 12.8 | 117.7 ± 13.2 | 117.3 ± 11.1 | <0.001 | NS | NS | <0.01 |
| Diastolic Blood Pressure (mmHg) | 76.8 ± 8.4 | 72.7 ± 11.5 | 71.9 ± 9.1 | 72.0 ± 8.2 | <0.05 | NS | NS | <0.01 |
| Weight (kg) | 66.5 ± 11.5 | 66.5 ± 11.2 | 66.7 ± 11.6 | 66.4 ± 11.5 | NS | NS | NS | NS |
| Body Mass Index (kgm−2) | 24.8 ± 3.6 | 24.8 ± 3.5 | 24.8 ± 3.7 | 24.7 ± 3.8 | NS | NS | NS | NS |
| Waist circumference (cm) | 86.6 ± 10.6 | 85.5 ± 9.1 | 85.6 ± 9.4 | 85.6 ± 8.8 | NS | NS | NS | NS |
| Hip circumference (cm) | 97.8 ± 9.0 | 96.4 ± 8.4 | 96.2 ± 8.9 | 96.0 ± 9.3 | <0.05 | NS | NS | <0.05 |
| Waist to Hip ratio | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | NS | NS | NS | NS |
| Haemoglobin (g/dl) | 14.3 ± 1.6 | NM | NM | 14.5 ± 1.8 | – | – | – | NS |
| White blood cell count (*109 per mm3) | 6.1 ± 0.5 | NM | NM | 6.3 ± 0.9 | – | – | – | NS |
| Platelet count (*109 per mm3) | 202.8 ± 10.7 | NM | NM | 208.4 ± 18.4 | – | – | – | NS |
| Fasting blood glucose (mg/dl) | 91.2 ± 6.9 | 94.5 ± 11.7 | 93.0 ± 7.6 | 92.7 ± 9.6 | NS | NS | NS | NS |
| Serum creatinine (mg/dl) | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.8 ± 0.2 | 0.9 ± 0.2 | NS | NS | NS | NS |
| AST (U/l) | 27.9 ± 7.3 | 29.7 ± 7.7 | 29.2 ± 7.5 | 27.6 ± 6.3 | NS | NS | NS | NS |
| ALT (U/l) | 21.0 ± 10.9 | 23.4 ± 10.9 | 21.7 ± 10.5 | 19.2 ± 11.2 | NS | NS | NS | NS |
| Serum bilirubin (mg/dl) | 0.8 ± 0.4 | 0.6 ± 0.3 | 0.5 ± 0.4 | 0.7 ± 0.4 | NS | NS | NS | NS |
| PT/INR | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | NS | NS | NS | NS |
| Total cholesterol (mg/dl) | 226.4 ± 38.7 | NM | NM | 210.24 ± 50.9 | – | – | – | <0.05 |
| LDL cholesterol (mg/dl) | 152.8 ± 37.1 | NM | NM | 129.8 ± 47.4 | – | – | – | <0.001 |
| HDL cholesterol (mg/dl) | 52.7 ± 14.2 | NM | NM | 61.8 ± 21.4 | – | – | – | NS |
| VLDL cholesterol (mg/dl) | 24.6 ± 15.2 | NM | NM | 27.6 ± 22.7 | – | – | – | NS |
| Triglycerides (mg/dl) | 112.1 ± 49.9 | NM | NM | 115.0 ± 47.9 | – | – | – | NS |
ALT Alanine aminotransferase, AST Aspartate aminotransferase, CZ Cinnamomum zeylanicum, HDL High Density Lipoprotein, LDL Low Density Lipoprotein, INR International Normalized Ratio, NM Not Measured, NS Not Significant, PT Prothrombin Time, VLDL Very Low Density Lipoprotein; *P1 – Baseline vs Visit 1; *P2 – Visit 1 vs Visit 2; *P3 – Visit 2 vs Visit 3; *P4 – Visit 0 vs Visit 3