Table 1.

Protein sites with relevant effects on the BN host variable.

Genotype	ORF	Protein sitesa	Standardized total effectsb
HEV3	ORF 1	89, 113, 509, 546, 547, 555, 557, 598, 605, 721, 746, 765, 782, 784, 796, 846, 1017, 1018, 1219, 1252, 1285, 1370 and 1508	0.459–0.0784
	ORF 2	5, 11, 13, 25 and 529	0.177–0.069
	ORF 3	82, 88 and 89	0.188–0.125
HEV4	ORF 1	161, 304, 462, 469, 488, 516, 546, 555, 557, 566, 573, 611, 620, 676, 683, 687, 720, 727, 736, 738, 740, 742, 743, 745, 755, 759, 762, 767, 769, 773, 774, 779, 781, 783, 786, 789, 790, 906, 938, 964, 1003, 1007, 1036, 1237, 1242, 1346, 1349, 1356, 1632, 1692 and 1704	0.5140–0.081
	ORF 2	11, 37, 39, 537, 597, 609 and 632	0.182–0.081
	ORF 3	70, 73, 92, 94 and 103	0.298–0.081

^aNumbering represent protein positions in respective ORFs. Listed sites correspond to BN_HEV3 and BN_HEV4 (Fig. 1).

^bRange of estimated values observed for corresponding protein sites (see Section 2 for further details on estimates).