Table 5.
Overall performance of BNC’s for different ORF1-domains.
| Domain | HEV3 |
HEV4 |
||||
|---|---|---|---|---|---|---|
| Protein sitesa | F-measure Swine/Human | CAb (%) | Protein sitesa | F-measure Swine/Human | CAb (%) | |
| Mt | 70, 81, 89, 129, 137, 141, 151, 152, 158, 161, 189, 192, 200 and 206 | 0.51/0.72 | 64.6 | 61, 72, 75, 89, 122, 139, 148, 150, 189 and 204 | 0.0/0.83 | 70.9 |
| Y | 219, 240, 246, 248, 302, 323, 355, 363, 393, 399 and 400 | 0.29/0.75 | 63.1 | 239, 248, 274, 277, 304, 306, 332, 335, 338, 340, 356, 357, 359, 363, 413, 423, 428 and 429 | 0.56/0.87 | 80.0 |
| Plp | 468, 495, 502, 509, 512, 514, 517, 530, 542, 557 and 589 | 0.69/0.77 | 73.8 | 462, 546, 560, 562 and 574 | 0.79/0.91 | 87.3 |
| Pp | 719, 720, 724, 728, 740, 749, 764, 775, 783, 790, 791, 795 and 797 | 0.83/0.86 | 84.6 | 707, 718, 732, 733, 742, 756, 760, 767, 772 and 779 | 0.77/0.90 | 85.5 |
| Md | 843, 855, 873, 876, 879, 914, 915, 941, 949, 959, 972, 985 and 992 | 0.52/0.77 | 69.2 | 803, 804, 811, 817, 835, 836, 846, 869, 874, 876, 902, 942 and 952 | 0.31/1.0 | 80.0 |
| Hel | 1016, 1024, 1043, 1076, 1101, 1146, 1160, 1233, 1234 and 1242 | 0.59/0.72 | 66.2 | 977, 981, 983, 984, 1003, 1007, 1044, 1047, 1064, 1094, 1096, 1100, 1117, 1120, 1124, 1136 and 1196 | 0.64/0.88 | 81.8 |
| Pol | 1370, 1285, 1508, 1599, 1732, 1386, 1612, 1283, 1481, 1533, 1746, 1426, 1652, 1499, 1638 and 1555 | 0.79/0.83 | 81.5 | 1235, 1236, 1247, 1266, 1303, 1355, 1360, 1447, 1456, 1572, 1632, 1648, 1652, 1692, 1693 and 1704 | 0.67/0.89 | 83.6 |
a
Site numbering based on polyprotein positions.
b
Overall classification accuracy of classification by 10-fold CV.