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. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Biochemistry. 2016 Dec 27;56(1):324–333. doi: 10.1021/acs.biochem.6b01107

Figure 3. Overview of dipeptide-20S interactions.

Figure 3

(A) Comparison of DPLG-2 bound active site with apo-Mtb20SOG. No significant conformational change was observed in the S1, S2, S3, or S4 sites. DPLG-2 form is in green; apo-form is in wheat. (B) Overview of inhibitor-occupied binding pockets. All six inhibitors are aligned in accordance with the DPLG-2 bound structure. The two β-subunits forming the inhibitor binding sites are shown in green and cyan; Thr-1 is in magenta. (C) The P1 naphthyl groups in the S1 binding pocket. (D) The P3 groups of six inhibitors in the S3 binding pocket.