Table 1.

IC₅₀’s of dipeptides against Mtb20SOG and β5c, β5i of the human c-20S and i-20S. The MG-132 values were measured for comparison.

	IC50 (μM) **			SIapp	SIapp
	Mtb20SOG (LLVY)	c-20S β5c (LLVY)	i-20S β5i (ANW)	$\frac{\text{IC}{50}_{\mathrm{\beta }5\mathrm{c}}}{\text{IC}{50}_{\text{Mtb}20\text{SOG}}}$	$\frac{\text{IC}{50}_{\mathrm{\beta }5\mathrm{i}}}{\text{IC}{50}_{\text{Mtb}20\text{SOG}}}$
DPLG-2 *	0.015	70.00	54.70	4667	3647
PKS2169	0.041 ± 0.006	29.2 ± 6.6	3.75 ± 0.60	712	91
PKS2144	0.010 ± 0.002	0.657 ± 0.087	0.007 ± 0.001	65.7	0.7
PKS2205	0.023 ± 0.002	20.95 ± 6.92	2.64 ± 0.62	911	115
PKS2206	0.016 ± 0.001	2.57 ± 0.75	0.044 ± 0.020	161	2.8
PKS2208	0.016 ± 0.002	14.34 ± 3.81	0.512 ± 0.157	896	32
MG-132	1.714 ± 0.079	0.008 ± 0.001	0.024 ± 0.001	0.005	0.014

^*Data from ²⁰.

^**Data are given as mean ± SEM.

ANW: Ac-ANW-AMC

LLVY: suc-LLVY-AMC

SI^app: apparent selectivity index