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. 2017 Nov;12(11):1749–1761. doi: 10.4103/1673-5374.219025

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Altered expression of circulating microRNAs in human patients with mild and severe TBI (based on the studies reviewed).

For mild TBI: Increased levels of miR-93, -191, -499 at 0–24 hours, days 2–7 post-injury; miR-151-5p, -195, -20a, -328, -362-3p, -30d, -451, -486, -505*, -92a at 0–24 hours post-injury; miR-16 at 0-10 hours post-injury; decreased levels of miR-425-p, -502 at 0–1 hour, 4–12 hours post-injury, miR-23b at 0–24 hours post-injury. For severe TBI: Increased levels of miR-21 at 4–12 hours, 48–72 hours post-injury; miR-335 at 0–1 hour, 4–12 hours, 48–72 hours post-injury; miR-93, -191, -499 at 0–24 hours, days 2–7 post-injury; miR-151-5p, -195, -20a, -328, -362-3p, -30d, -451, -486, -505* at 0–48 hours post-injury; miR-92a at 0-48 hours (mean 26 hours) post-injury; miR-765 mean 68 hours post-injury; decreased levels of miR-23b at 0-24 hours post-injury; miR-16, -92a at mean 68 hours post-injury.