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. 2017 Nov;12(11):1870–1876. doi: 10.4103/1673-5374.219049

Figure 5.

Figure 5

Effect of calycosin on hippocampal inflammatory factor in APP/PS1 mice assessed by enzyme linked immunosorbent assay.

(A) Levels of interleukin-1 (IL-1) protein and (B) levels of tumor necrosis factor-alpha (TNF-α) protein. Results are expressed as the mean ± SD (n = 12; one-way analysis of variance followed by Tukey's multiple range test). *P < 0.05, **P < 0.01, vs. group IV; ##P < 0.01, vs. group VII. Group I: Untreated C57BL/6 mice; group II: C57BL/6 with daily vehicle; group III: C57BL/6 mice treated with calycosin 50 mg/kg; group IV: APP/PS1 mice; groups V, VI, VII: APP/PS1 mice treated with calycosin 10, 20 and 30 mg/kg daily, respectively; group VIII: calycosin 40 mg/kg + calphostin C (a selective protein kinase C inhibitor, 0.1 μg in 3 μL 0.5% dimethyl sulfoxide per mouse).