Table 1.

GWAS on the genetic mechanism of chronic hepatitis B

	Ethnicity	SNP	Chromosome (locus)	Odds ratio	P value (combined stage)	References
1	Japanese Korean Indonesian	rs9277535	6 (HLA-DPB1)	1.39–1.89	3.0 × 10−54 −3.0 × 10−12	[10–12] [18, 19]
2	Japanese East Asian Korean	rs3077	6 (HLA-DPA1)	1.78–1.89	2.0 × 10−61 −2.0 × 10−38	[10–12] [14, 17, 18]
3	Japanese Korean	rs2856718	6 (TRNAI25)	1.56–1.60	4.0 × 10−37 2.0 × 10−24	[11, 12] [17, 18]
4	Japanese Korean Chinese	rs7453920	6 (HLA-DQB2)	1.81–2.00	5.0 × 10−37 ~7.0 × 10−26	[11, 12, 16] [17, 18]
5	Korean	rs1419881	6 (TCF19)	1.37	1.0 × 10−18	[12, 18]
6	Korean	rs652888	6 (EHMT2)	1.38	7.0 × 10−13	[12, 18]
7	Korean	rs9394021	6 (VARS2)	0.78	1.7 × 10−6	[13]
8	Korean	rs2517459	6 (VARS2-SFTA2)	0.56	1.7 × 10−10	[13]
9	East Asian	rs9277542	6 (HLA-DPB1)	1.64	2.0 × 10−21	[14]
10	Chinese	rs11866328	16 (GRIN2A)	1.68	2.0 × 10−8	[15]
11	Chinese	rs4821116	22 (UBE2L3)	1.22	2.0 × 10−12	[16]
12	Chinese	rs3130542	6 (TRNAI25)	1.33	9.0 × 10−14	[16, 18]
13	Chinese	rs352140	3 (TLR9)	0.70	8.8 × 10−3	[17]
14	Chinese	rs16944	2 (IL1B)	0.67	1.6 × 10−2	[17]
15	Chinese	rs3212227	5 (IL12B)	1.38	2.1 × 10−2	[17]
16	Chinese	rs3799488	13 (IFNGR1)	1.48	4.8 × 10−3	[17]
17	Chinese	rs1059293	6 (IFNGR2)	0.27	1.1 × 10−2	[17]
18	Chinese	rs467960	21 (MX1)	0.68	2.2 × 10−2	[17]
19	Chinese	rs12614	6 (CFB)	1.89	1.28 × 10−34	[18]
20	Chinese	rs422951	6(NOTCH4)	1.27	5.33 × 10−16	[18]
21	Chinese	rs378352	6 (HLA-DOA)	1.26	1.04 × 10−23	[18]
22	Chinese	rs2853953	6 (HLA-C)	1.47	5.06 × 10−20	[18]
23	Chinese	rs1883832	20 (CD40)	1.21	2.95 × 10−15	[18]
24	Indonesian	rs9267665	6 (HLA)	2.05	1.0 × 10−17	[19]
25	Chinese	rs477515	6 (TRNAI25)	2.05	3.0 × 10−19	[20]
26	Indonesian Chinese	rs3135363	6 (HLA-DR)	1.53,1.51	7.0 × 10−22 8.0 × 10−7	[19, 20]