Fig. 8.

Proposed outline of the Survivin overexpression phenotype. a: Normal chromosomal segregation of cells. During metaphase amphitelic kinetochore-microtubule (KT) connections provide the foundation for correct sequential chromosome segregation and abscission of daughter cells. b: Overexpression of Survivin stochastically induces false KT connections, such as merotelic connections. The resulting disturbed segregation of chromosomes during anaphase (i.e. lagging chromosomes) can result in trapped chromatin in midbodies. Such affected chromosomes become damaged either by microtubule-generated forces or by cleavage furrow-generated forces. Mechanistically, the “No cut”-pathway of midbody-trapped chromatin could prevent abscission, which promotes the development of polyploid cells with supernumerary centrosomes