Table 6.
Survey of symptoms: dry eye disease versus control populations (all enrolled population)
| Time Period | Category | Statistic | All cases (n = 217) | All controls (n = 67) | P-value |
|---|---|---|---|---|---|
| Past Week | |||||
| Stinging/Burning | |||||
| Experienced, n (%) | None of the time | 50 (23.04) | 58 (86.57) | <0.0001 | |
| Some of the time | 103 (47.47) | 8 (11.94) | |||
| Half of the time | 31 (14.29) | 0 (0.00) | |||
| Most of the time | 21 (9.68) | 1 (1.49) | |||
| All of the time | 8 (3.69) | 0 (0.00) | |||
| Missing | 4 (1.84) | 0 (0.00) | |||
| Bothered | N | 209 | 63 | <0.0001 | |
| Mean (SD) | 1.49 (1.097) | 0.19 (0.503) | |||
| Dryness | |||||
| Experienced, n (%) | None of the time | 12 (5.53) | 53 (79.10) | <0.0001 | |
| Some of the time | 73 (33.64) | 10 (14.93) | |||
| Half of the time | 43 (19.82) | 3 (4.48) | |||
| Most of the time | 58 (26.73) | 0 (0.00) | |||
| All of the time | 28 (12.90) | 0 (0.00) | |||
| Missing | 3 (1.38) | 1 (1.49) | |||
| Bothered | N | 210 | 63 | <0.0001 | |
| Mean (SD) | 2.17 (1.143) | 0.24 (0.560) | |||
| Foreign Body Sensation | |||||
| Experienced, n (%) | None of the time | 31 (14.29) | 55 (82.09) | <0.0001 | |
| Some of the time | 117 (53.92) | 11 (16.42) | |||
| Half of the time | 33 (15.21) | 0 (0.00) | |||
| Most of the time | 20 (9.22) | 1 (1.49) | |||
| All of the time | 13 (5.99) | 0 (0.00) | |||
| Missing | 3 (1.38) | 0 (0.00) | |||
| Bothered | N | 209 | 63 | <0.0001 | |
| Mean (SD) | 1.66 (1.170) | 0.25 (0.671) | |||
| Itching | |||||
| Experienced, n (%) | None of the time | 50 (23.04) | 47 (70.15) | <0.0001 | |
| Some of the time | 88 (40.55) | 18 (26.87) | |||
| Half of the time | 36 (16.59) | 1 (1.49) | |||
| Most of the time | 32 (14.75) | 1 (1.49) | |||
| All of the time | 8 (3.69) | 0 (0.00) | |||
| Missing | 3 (1.38) | 0 (0.00) | |||
| Bothered | N | 205 | 63 | <0.0001 | |
| Mean (SD) | 1.43 (1.168) | 0.37 (0.679) | |||
| Light Sensitivity | |||||
| Experienced, n (%) | None of the time | 39 (17.97) | 56 (83.58) | <0.0001 | |
| Some of the time | 86 (39.63) | 11 (16.42) | |||
| Half of the time | 35 (16.13) | 0 (0.00) | |||
| Most of the time | 33 (15.21) | 0 (0.00) | |||
| All of the time | 21 (9.68) | 0 (0.00) | |||
| Missing | 3 (1.38) | 0 (0.00) | |||
| Bothered | N | 207 | 63 | <0.0001 | |
| Mean (SD) | 1.74 (1.265) | 0.21 (0.513) | |||
| Painful/Sore | |||||
| Experienced, n (%) | None of the time | 98 (45.16) | 61 (91.04) | <0.0001 | |
| Some of the time | 77 (35.48) | 6 (8.96) | |||
| Half of the time | 22 (10.14) | 0 (0.00) | |||
| Most of the time | 14 (6.45) | 0 (0.00) | |||
| All of the time | 2 (0.92) | 0 (0.00) | |||
| Missing | 4 (1.84) | 0 (0.00) | |||
| Bothered | N | 207 | 62 | <0.0001 | |
| Mean (SD) | 1.01 (1.106) | 0.11 (0.409) | |||
| Intermittent Blurred Vision | |||||
| Experienced, n (%) | None of the time | 37 (17.05) | 57 (85.07) | <0.0001 | |
| Some of the time | 104 (47.93) | 8 (11.94) | |||
| Half of the time | 44 (20.28) | 2 (2.99) | |||
| Most of the time | 18 (8.29) | 0 (0.00) | |||
| All of the time | 10 (4.61) | 0 (0.00) | |||
| Missing | 4 (1.84) | 0 (0.00) | |||
| Bothered | N | 206 | 61 | <0.0001 | |
| Mean (SD) | 1.67 (1.175) | 0.16 (0.522) | |||
| Tired/Fatigued Eyes | |||||
| Experienced, n (%) | None of the time | 23 (10.60) | 43 (64.18) | <0.0001 | |
| Some of the time | 108 (49.77) | 21 (31.34) | |||
| Half of the time | 32 (14.75) | 2 (2.99) | |||
| Most of the time | 39 (17.97) | 0 (0.00) | |||
| All of the time | 11 (5.07) | 1 (1.49) | |||
| Missing | 4 (1.84) | 0 (0.00) | |||
| Bothered | N | 208 | 62 | <0.0001 | |
| Mean (SD) | 1.75 (1.109) | 0.37 (0.752) | |||
| Frequent Blinking | |||||
| Experienced, n (%) | None of the time | 52 (23.96) | 60 (89.55) | <0.0001 | |
| Some of the time | 72 (33.18) | 6 (8.96) | |||
| Half of the time | 40 (18.43) | 1 (1.49) | |||
| Most of the time | 31 (14.29) | 0 (0.00) | |||
| All of the time | 18 (8.29) | 0 (0.00) | |||
| Missing | 4 (1.84) | 0 (0.00) | |||
| Bothered | N | 207 | 61 | <0.0001 | |
| Mean (SD) | 1.34 (1.188) | 0.10 (0.300) | |||
| Other | |||||
| Experienced, n (%) | None of the time | 55 (25.35) | 40 (59.70) | <0.0001 | |
| Some of the time | 2 (0.92) | 0 (0.00) | |||
| Half of the time | 6 (2.76) | 0 (0.00) | |||
| Most of the time | 6 (2.76) | 0 (0.00) | |||
| All of the time | 2 (0.92) | 0 (0.00) | |||
| Missing | 146 (67.28) | 27(40.30) | |||
| Bothered | N | 70 | 39 | 0.0015 | |
| Mean (SD) | 0.69 (1.314) | 0.00 (0.000) |
“Bothered” evaluated by the patient using a 5-point scale where 0 = not at all and 4 = extremely