Table 1.
Comparison of Hematologic and Morphologic Features Between Early and Late Relapse Patients
| Early Relapse (<6 months) n = 10 |
Late Relapse (>6 months) n = 11 |
p-value | |
|---|---|---|---|
| Age at transplant, years, median (range) | 67 (34–71) | 58 (46–61) | 0.013 |
| Gender, M:F | 5:5 | 6:5 | NS |
| Time to relapse from transplant, months, median (range) | 3 (2–6) | 15 (6–82) | <0.001 |
| Pre-transplant MDS specimen, peripheral blood and bone marrow characteristics | |||
| Hgb, g/dL, median(range) | 9.0 (7.6–12.7) | 9.3 (5.6–12.9) | NS |
| MCV, fL, median (range) | 89 (73–109) | 101 (86–107) | 0.023 |
| WBC, × 109/L, median (range) | 3.0 (1.1–10.2) | 3.3 (1–33) | NS |
| ANC, × 109/L, median (range) | 0.9 (0.1–7.8) | 1.1 (0.4–24.1) | NS |
| Platelets, × 109/L, median (range) | 36 (10–1242) | 89 (5–206) | NS |
| Blood blasts, %, median (range) | 1 (0–16) | 0.5 (0–13) | NS |
| Dysgranulopoiesisa | 4/7 | 3/8 | NS |
| Dyserythropoeisisa | 5/7 | 6/8 | NS |
| Dysmegakaryopoiesisa | 4/6 | 5/3 | NS |
| Ring sideroblastsa | 4/8 | 4/9 | NS |
| Marrow cellularity, %, median (range) | 90 (15–95) | 43 (30–95) | 0.075 |
| Bone marrow blasts, %, median (range) | 4 (1–19) | 7 (2–14) | NS |
| Increased marrow blasts (>5%) | 7/10 (70%) | 8/11 (72%) | NS |
| Relapse myeloid neoplasm specimen, peripheral blood and bone marrow characteristics | |||
| Hgb, g/dL, median(range) | 10.0 (8.6–12.2) | 9.8 (8.1–13) | NS |
| MCV, fL, median (range) | 88 (80–105) | 99 (87–113) | 0.051 |
| WBC, × 109/L, median (range) | 2.2 (0.6–7.6) | 2.5 (1.5–3.4) | NS |
| ANC, × 109/L, median (range) | 1.3 (0.2–5.9) | 1.2 (0.2–2.5) | NS |
| Platelets, × 109/L, median (range) | 20 (7–128) | 66 (10–189) | 0.061 |
| Blood blasts, %, median (range) | 0.3 (0–15) | 2 (0–38) | NS |
| Dysgranulopoiesisa | 3/9 | 2/11 | NS |
| Dyserythropoeisisa | 5/9 | 6/11 | NS |
| Dysmegakaryopoiesisa | 7/8:5/8 | 6/10:3/10 | NS |
| Ring sideroblastsa | 6/6 | 1/3 | 0.033 |
| Marrow cellularity, %, median (range) | 48 (20–90) | 45 (10–90) | NS |
| Bone marrow blasts, %, median (range) | 5 (0.2–30) | 14 (4–51) | 0.029 |
| Increased marrow blasts (>5%) | 5/10 (50%) | 10/11 (91%) | 0.063 |
Bold indicates statistical significance
aAny degree of dysplasia ≥10% of a lineage. See text (materials and methods section) for specific dysplastic features included for this study; “n” for dysplasia and ring sideroblast evaluation varies for each category depending on the slides and number of precursors in each lineage available for review