Table 2.
Procedures of HR or TACE groups
| Study | TACE | HR | ||
|---|---|---|---|---|
| Duration and interval | Chemotherapeutic agents | Embolic agents | Methods and procedure | |
| Fan 2001 [20] | Median 2 times (ranged 1-4) | 5-fluorouracil (5-Fu) 1000 mg, mitomycin (MMC) 12 to20 mg, cisplatin or carborplatinum 80 mg |
Lipiodol 20 ml | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Fan 2003 [19] | Median 2-3 times (ranged 1-7) | 5-fluorouracil (5-Fu) 1000-1500 mg, cisplatin 80-100 mg, mitomycin (MMC) 8 to20 mg or doxorubicin 80 mg |
Lipiodol 2-20 ml | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Cheng 2005 [18] | NA | Cisplatin, doxorubicin and mitomycin | Lipiodol | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Fan 2005 [21] | Ranged 1-7 times | 5-fluorouracil (5-Fu) 1000-1500 mg, cisplatin 80-100 mg, mitomycin (MMC) 8-20 mg or epiadriamycin 40-60 mg | Lipiodol 5-20 ml | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Zhou 2011 [25] | Every 1-2 months for 2-5 cycles. | 5-fluorouracil (500 mg /m2) and Adriamycin (30 mg/m2) | Gelatin sponge particles (1 mm3) | Hepatectomy plus thrombectomy |
| Peng 2012 [12] | Mean of 2.1 (ranged 1-5) | Carboplatin 300 mg, epirubicin 50 mg and mitomycin C 8 mg |
Gelatin sponge particles (1 to 2 mm in diameter) Lipiodol 5 mL |
Hepatectomy plus thrombectomy |
| Liu PH 2014 [22] | NA | Adriamycin 20–30 mg | Lipiodol 5-10 ml Gelfoam (2–3-mm strips) |
En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Liu K 2014 [17] | NA | Cisplatin 50-100 mg and epirubicin 20-40 mg | Lipiodol 5-20 ml | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Ye 2014 [24] | 1 month intervals (ranged 1-7) | Doxorubicin 30-50 mg and cisplatinum 50-100 mg | Lipiodol 10-20 ml and gelfoam particles | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |
| Lee 2016 [13] | Every 4 weeks | Doxorubicin 50 mg | Lipiodol | Hepatectomy plus thrombectomy |
| Zheng 2016 [1] | Mean of 2.9 (ranged 1–7) | NA | Gelatin sponge | Hepatectomy plus thrombectomy |
| Wang 2016 [11] | Intervals of 6 to 8 weeks | Doxorubicin hydrochloride 20-60 mg, and cisplatin 5 mg | Lipiodol 5-30 ml and gelfoam fragments | En-bloc resection, partial hepatectomy or hemihepatectomy Thrombectomy |