Table 1.

Least-Squares Mean (LS-Mean) of Changes from Baseline in Mexican-American Patients with Major depression Who Received Desipramine or Fluoxetine^a

Group	Week	HAM-D				HAM-A				BDI				CESD				GAS
		N	LS-Mean	SE	P	N	LS-Mean	SE	P	N	LS-Mean	SE	P	N	LS-Mean	SE	P	N	LS-Mean	SE	P
Longitudinal analysis of observed datab
Desipramine	1	111	−1.5	0.5	0.447	107	−0.8	0.6	0.516	100	−1.9	0.6	0.690	109	−1.0	0.8	0.415
Fluoxetine	1	120	−2.0	0.5		116	−1.3	0.6		111	−1.6	0.6		115	−1.8	0.8
Desipramine	2	105	−4.2	0.5	0.836	102	0.2	1.5	0.054	96	−4.9	0.7	0.153	100	−3.1	0.8	0.382
Fluoxetine	2	113	−4.3	0.5		111	−3.9	1.5		104	−3.4	0.7		106	−4.1	0.8
Desipramine	3	99	−6.2	0.5	0.848	98	−2.8	0.6	0.061	92	−6.8	0.8	0.780	95	−5.7	0.8	0.732
Fluoxetine	3	110	−6.0	0.5		105	−4.4	0.6		97	−6.5	0.8		104	−6.1	0.8
Desipramine	4	97	−7.3	0.5	0.633	95	−3.8	0.6	0.143	88	−8.5	0.9	0.567	92	−7.0	0.8	0.906	96	7.7	0.9	0.413
Fluoxetine	4	106	−7.6	0.5		101	−5.1	0.6		96	−7.8	0.9		103	−7.1	0.8		103	8.7	0.9
Desipramine	5	86	−9.3	0.6	0.531	88	−5.7	0.7	0.065	84	−10.1	0.9	0.916	82	−8.5	0.9	0.024
Fluoxetine	5	100	−9.8	0.5		97	−7.5	0.7		95	−10.3	0.9		91	−11.1	0.8
Desipramine	6	82	−10.0	0.6	0.159	81	−5.8	0.7	0.016	77	−9.7	0.9	0.045	75	−8.6	0.9	0.006
Fluoxetine	6	95	−11.1	0.5		89	−8.2	0.7		88	−12.1	0.8		86	−11.9	0.8
Desipramine	7	75	−10.5	0.6	<.001	74	−6.1	0.7	<.001	75	−11.8	0.8	0.035	71	−10.2	0.9	0.005
Fluoxetine	7	93	−13.2	0.5		88	−9.7	0.7		83	−14.2	0.8		86	−13.7	0.9
Desipramine	8	74	−12.0	0.6	0.001	72	−7.4	0.7	<.001	71	−12.2	0.9	0.014	72	−11.1	0.9	0.064	64	18.5	1.0	0.002
Fluoxetine	8	92	−14.6	0.5		90	−10.6	0.6		85	−15.3	0.9		81	−13.4	0.9		83	22.9	0.9

^aLeast-squares mean change from baseline was calculated after adjustment for gender, age and baseline score. SE=Standard error.

^bMixed-effects model for repeated measures (MMRM) included all available observations on all subjects at all time points.