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. 2017 Nov 10;8(64):107374–107389. doi: 10.18632/oncotarget.22376

Figure 3. PPF curcumin is pharmacologically safe as assessed by acute and chronic toxicity studies in Swiss albino mice.

Figure 3

(A) Histopathological analysis of liver tissues of mice administered with 25 mg/kg or 125 mg/kg liposomal curcumin, PPF-curcumin or the void carrier, during acute toxicity study (7 days). (B) Histopathological analysis of the liver tissues of mice subjected to chronic toxicity study for 2 months using 25 mg/kg or 50 mg/kg liposomal curcumin, PPF-curcumin or void carrier. (C) Liver function parameters of mice subjected to acute toxicity study using 25 mg/kg or 125 mg/kg liposomal curcumin, PPF-curcumin or the void carrier. (D) Liver function parameters of mice subjected to chronic toxicity study using 25 mg/kg or 50 mg/kg liposomal curcumin, PPF-curcumin or the void carrier.