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. 2017 Nov 10;8(64):107374–107389. doi: 10.18632/oncotarget.22376

Figure 4. PPF-curcumin causes significant sensitization of HeLa xenograft tumors in NOD-SCID mice to paclitaxel treatment.

Figure 4

(A) Representative images of NOD-SCID mice bearing HeLa xenograft tumors, after 4 weeks of treatment. (B) Graph showing tumor volumes of NOD-SCID mice bearing HeLa xenograft tumors with or without treatment during the span of study. Combination treatment significantly (p-values ≤ 0.001) reduced the tumor volume in comparison to control and blank treated mice. (C) Immunohistochemical staining of PCNA, p65, cyclin D1 and VEGF in the tumor tissues of different treatment groups, which shows that PPF-curcumin efficiently down-regulates paclitaxel-mediated activation of survival signals in HeLa xenograft tumors in NOD-SCID mice. The quantification of the IHC images were done using ImageJ software. The results of three independent data sets are compiled as graphs. The values shown are average ± SD for 3 independent images/fields.