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. 2017 Nov 21;8(64):107666–107677. doi: 10.18632/oncotarget.22587

Figure 1. Ivermectin suppressed the growth of GC cells in vitro and in a xenograft mouse model.

Figure 1

(A) Sensitivity of GC cells to ivermectin. Cell viability was measured by MTT assays in GC cells treated with the indicated concentrations of ivermectin for 48 h. (B) Top, Colony formation assays. Cells were cultured with the indicated concentrations of ivermectin for 10 days. Bottom, Total number of colonies. **P < 0.005, ***P < 0.0005. (C–G) Nude mice were inoculated with MKN1 cells and treated with ivermectin or control. (C) MKN1 tumor growth in mice treated with ivermectin or control. **P < 0.005, ***P < 0.0005. (D) Subcutaneous tumors from control and ivermectin-treated mice. (E) Tumor weights at time of sacrifice. *P < 0.05. (F) Body weights of control and ivermectin-treated mice during the entire experimental period (22 days). *P < 0.05. (G) Left, Immunohistochemical staining for YAP1 and Ki67 in tumor tissues from control and ivermectin-treated mice. Original magnification, ×400. Right, Data obtained by counting nuclear YAP1- and Ki67-positive tumor cells/tumor cells per fields. ***P < 0.0005.