Figure 2. The antiproliferative effects of ivermectin were dependent on YAP1 expression.

(A) Immunoblotting for total protein expression of YAP1 in YAP1 siRNA-transfected MKN1 and MKN7 cells and control siRNA-transfected cells. (B) MTT proliferation assays. The proliferation rates of YAP1 siRNA-transfected MKN1 and MKN7 cells were compared with that of control siRNA-transfected cells. ^*P < 0.05, ^***P < 0.0005. (C) IC₅₀ values and RIs for ivermectin in YAP1 siRNA-transfected MKN1 and MKN7 cells and control siRNA-transfected cells. RI; resistance index.