Table 2. Analysis of allelic association of rs9943582 with ischemic stroke.
| Cohort (n, case/control) | Number of Genotype | Freq _A (case/control) | Observed* | Adjust† | ||||
|---|---|---|---|---|---|---|---|---|
| Case | Control | P-obs | OR (95% CI) | P-adj | OR (95% CI) | |||
| Entire population (1158/1265) | AA | 97 | 92 | 0.263/0.256 | 0.57 | 1.04 (0.91–1.18) | 0.86 | 0.99 (0.87–1.13) |
| AG | 416 | 464 | ||||||
| GG | 645 | 709 | ||||||
| Male (683/779) | AA | 57 | 61 | 0.276/0.258 | 0.28 | 1.10 (0.93–1.29) | 0.69 | 0.97 (0.81–1.15) |
| AG | 263 | 278 | ||||||
| GG | 363 | 440 | ||||||
| Female (475/486) | AA | 40 | 30 | 0.245/0.253 | 0.69 | 0.96 (0.78–1.18) | 0.41 | 1.00 (0.88–1.36) |
| AG | 153 | 187 | ||||||
| GG | 282 | 269 | ||||||
| Non-Hypertension (521/789) | AA | 38 | 66 | 0.256/0.245 | 0.50 | 1.06 (0.89–1.27) | 0.50 | 0.94 (0.78–1.13) |
| AG | 191 | 254 | ||||||
| GG | 292 | 469 | ||||||
| Hypertension (637/476) | AA | 59 | 26 | 0.269/0.275 | 0.75 | 0.97 (0.80–1.17) | 0.24 | 1.13 (0.92–1.38) |
| AG | 225 | 210 | ||||||
| GG | 353 | 240 | ||||||
Freq _A: Frequency of A allele.
*Uncorrected P value and odds ratio (OR) using Chi-square tests with Pearson's 2 × 2.
†Adjusted P value by multivariate logistic regression analysis for potential confounders including age, gender, smoking, hypertension, diabetes mellitus and lipid concentrations (Tch, TG, HDL-c and LDL-c).