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. 2017 Nov 11;8(64):107907–107919. doi: 10.18632/oncotarget.22392

Figure 6. YAP1 regulates tumorigenicity and lung metastatic potential in small cells but not large CRC cells.

Figure 6

(A-B) Transwell assays for large and small LoVo cells upon knocking down of YAP1. (L denotes large CRC cells, S denotes small CRC cells) Scale bars: 100 μm. Data are presented as mean ± SD; **P< 0.01. (C-D) Lung metastasis models of the effect of YAP1 knockdown. Representative images of lung metastases resulting from injection of large and small LoVo cells upon knocking down of YAP1 into NOD/SCID mice (n=6 per group). Data are presented as mean ± SD; ***P< 0.001. (E) Protein levels of E-cadherin, Vimentin, YAP1 and CD133 were analyzed using western blotting in large and small LoVo cells upon knocking down of YAP1. GAPDH was used as a loading control. (F) Kaplan-Meier analysis of the correlation of YAP1 with overall survival in colorectal cancer patients.