Table 1. Tumor-Initiating frequency of large and small CRC cells in Balb/c-nu mice.

Cells	10k	Cell dose		Tumor-initiating frequency(95% interval)a	P value
		1k	100
LoVo
Small	6/6	10/10	5/6	1/141(1/48-413)	8.79e-12
Large	9/10	3/4	0/10	1/8470(1/3547-15593)
HT-29
Small	9/10	5/6	0/6	1/2468(1/1038-5871)	0.242
Large	9/10	2/10	0/6	1/4454(1/2238-8865)

Note. Purified large and small CRC cells were implanted subcutaneously in female Balb/c-nu mice and all tumors were harvested 6 weeks post-implantation.

^a Tumor-initiating frequency was determined using Bioinformatics Division ELDA analyzer (http://bioinf.wehi.edu.au/software/elda/index.html).