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. 2017 Nov 14;8(64):107977–107990. doi: 10.18632/oncotarget.22439

Figure 6. In vivo study of SHR8443 in mouse xenograft models.

Figure 6

(A, B) Pharmacokinetic/pharmacodynamic studies of SHR8443. U-87MG tumor-bearing mice were orally administered a single 10-mg/kg dose of SHR8443 and sacrificed at the indicated times. The concentration of SHR8443 in blood plasma and tumor tissues was determined (A). In parallel, tumor extracts were analyzed by Western blotting (B). (C) Antitumor activity of SHR8443 against xenografts. U-87MG, PC-3, A549, BT-474 and BT-474/trastuzumab tumor-bearing mice were orally administered BEZ235 or SHR8443 daily, or intravenously injected with trastuzumab twice a week. Tumor volumes were measured twice a week. *P < 0.05, **P < 0.01 versus vehicle.