Table 1. Enzymatic assays of inhibition of PI3K family members by SHR8443.

Kinase	IC50 (nM)
	SHR8443	BEZ235
mTOR	7.8 ± 1.1	28.9 ± 0.0
PI3Kα	0.1 ± 0.0	20.6 ± 4.7
PI3Kβ	15.8 ± 3.8	59.1 ± 23.8
PI3Kδ	0.7 ± 0.2	9.5 ± 7.3
PI3Kγ	0.2 ± 0.2	6.3 ± 0.0

Note: Values are means ± SD (n = 3).