Table 1. Characteristics of LS sample series.

	Predisposing gene			MMR status		CIMP status*
	MLH1	MSH2	MSH6	MSI (high)	MSS	Negative	Positive	ND
Colorectal specimens (n = 29)	22 (76 %)	3 (10 %)	4 (14 %)	29 (100 %)	0	18 (62 %)	11 (38 %)	0
Adenoma (n = 11)	10 (91 %)	1 (9 %)	0	11 (100 %)	0	9 (82 %)	2 (18 %)	0
Carcinoma (n = 18)	12 (67 %)	2 (11 %)	4 (22 %)	18 (100 %)	0	9 (50 %)	9 (50 %)	0
Ovarian carcinoma (n = 16)	13 (81 %)	3 (19 %)	0	16 (100 %)	0	12 (75 %)	3 (19 %)	1 (6 %)
Total (n = 45)	35 (78 %9	6 (13 %)	4 (9 %)	45 (100 %)	0	30 (67 %)	14 (31 %)	1 (2 %)

^*Determined by MS-MLPA (ME042-B2 for colorectal tumors and ME001-C1 for ovarian carcinomas; see Materials and Methods).

ND, could not be determined due to shortage of DNA.