Table 3. Average numbers of somatic non-synonymous mutations and mutant genes among 578 cancer-relevant genes investigated.

	Average no. of non-synonymous mutations	p-value	Average no. of mutant genes (any frequency for mutant alleles)	p-value	Average no. of mutant genes (frequency ≥ 25 % for mutant alleles)	p-value
Colorectal adenoma (n = 11)	1442		370		78
CIMP-negative (n = 9)	1433	ns	355	ns	58	ns (0.099)
CIMP-positive (n = 2)	1485		440		170
Colorectal carcinoma (n = 18)	1124		361		97
CIMP-negative (n = 9)	1050	ns	346	ns	77	ns
CIMP-positive (n = 9)	1198		375		118
Colorectal tumors combined (n = 29)	1245		364		90
CIMP-negative (n = 18)	1242	ns	351	ns	67	ns (0.076)
CIMP-positive (n = 11)	1250		387		128
Ovarian carcinoma (n = 16)*	657		162		30
CIMP-negative (n = 12)	252	0.014	99	0.014	25	0.030
CIMP-positive (n = 3)	2494		464		58
Colorectal and ovarian tumors combined (n = 45) *	954		287		70
CIMP-negative (n = 30)	846	0.011	250	0.019	50	0.004
CIMP-positive (n = 14)	1517		403		113

^*Includes one ovarian carcinoma with CIMP status unknown.

p-values were calculated by Mann-Whitney U test (ns, non-significant).

Case-by-case data on CIMP status vs. no. of mutations or mutant genes are shown in Supplementary Table 2.