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. 2017 Nov 21;8(64):108238–108248. doi: 10.18632/oncotarget.22602

Figure 6. MARCH8 was involved in PI3K/AKT signaling pathway and epithelial-mesenchymal transition (EMT) process.

Figure 6

(A) PI3K/AKT signaling related genes were down-regulated in the MARCH8 group, as well as the downstream genes related with cell proliferation. Meanwhile, overexpression of MARCH8 inhibited the expression of EMT related genes. Quantitative results of PI3K/AKT signaling related genes in A549 (B) and H1299 cells (C) are shown. The error bars indicate ± SEM. *P<0.05 by Student's t-test. Quantitative results of EMT related genes in A549 (D) and H1299 cells (E) are shown. The error bars indicate ± SEM. *P<0.05 by Student's t-test.