Table 5.

Neuropsychological evaluation and functional improvement

Patient	Treatment stage	The sphere of perception					Emotional reaction	The sphere of speech
		Reaction to the light	Eye leading after the objects or attendant	Head response to sound signal	Reaching the object	Hands
Patient 1	At admission	No	No	No	No	Stay clenched	—	No sound, aphonia, no crowing gurgling
	BMNCs	No	No	No	No	Stay clenched	—	No sound, aphonia, no crowing gurgling
	BMMSCs I	No	No	No	No	Stay clenched	—	No sound, aphonia, no crowing gurgling
	BMMSCs II	Appeared	An attempt to lead the eye	Yes	No	Stay clenched	Simple	An attempt to cry
	BMMSCs III	Appeared	An attempt to lead the eye	Yes	No	Relaxed	Simple	An attempt to cry
	BMMSCs IV	Appeared	Leading after interesting objects	Yes	Try to reach	Relaxed	Simple	Opening mouth for a sound signal, gurgling
Patient 2	At admission	Yes	No	No	No	Stay clenched	Impaired	Simple sound signals, loud crying
	BMNCs	Yes	No	No	No	Stay clenched	Impaired	Simple sound signals, loud crying
	BMMSCs I	Yes	An attempt to lead the eye	No	Try to reach	Stay clenched	Simple, concentrate easier	Simple sound signals, loud crying
	BMMSCs II	Yes	An attempt to lead the eye	No	Try to reach	Relaxed	Simple, concentrate easier	Simple sound signals, loud crying
	BMMSCs III	Yes	Leading after interesting objects, relatives	Yes	Try to reach	Relaxed	Simple, concentrate easier	Opening mouth for a sound signal, gurgling
	BMMSCs IV	Yes	Leading after interesting objects, relatives	Yes	Reaching the objects normally	Normal, relaxed	Express emotions as response on intense stimulus	Further improvement in complex sound signals, crying as a result of even minimal emotional impact
Patient 3	At admission	No	No	No	No	Stay clenched	—	No sound, aphonia, no crowing gurgling
	BMNCs	No	No	No	No	Stay clenched	—	An attempt to cry
	BMMSCs I	No	No	No	No	Stay clenched	—	An attempt to cry
	BMMSCs II	Appeared	An attempt to lead the eye	Yes	No	Stay clenched	Simple	Opening mouth for a sound signal, gurgling
	BMMSCs III	Appeared	An attempt to lead the eye	Yes	No	Relaxed	Simple	Opening mouth for a sound signal, gurgling
	BMMSCs IV	Appeared	Leading after interesting objects	Yes	Try to reach	Relaxed	Further	Simple sound signals, loud crying
Patient 4	At admission	Yes	No	No	Reaching the objects normally	Relaxed most of the time	Impaired	Simple sound signals, loud crying
	BMNCs	Yes	No	No	Reaching the objects normally	Relaxed most of the time	Impaired	Simple sound signals, loud crying
	BMMSCs I	Yes	An attempt to lead the eye	No	Reaching the objects normally	Relaxed most of the time	Simple	Simple sound signals, loud crying
	BMMSCs II	Yes	An attempt to lead the eye	Yes	Reaching the objects normally	Normal, relaxed	Simple	Simple sound signals, loud crying
	BMMSCs III	Yes	An attempt to lead the eye	Yes	Reaching the objects normally	Normal, relaxed	Simple	Simple sound signals, loud crying
	BMMSCs IV	Yes	Leading after interesting objects, relatives	Yes	Reaching the objects normally	Normal, relaxed	Further	Further improvement in complex sound signals, crying as a result of even minimal emotional impact

Abbreviation: —, no data; BMNCs, bone marrow nucleated cells; BMMSC, bone marrow mesenchymal stem cell.