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. 2017 Dec 20;7(1):68–77. doi: 10.1002/sctm.17-0149

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© 2017 The Authors stemcellstranslationalmedicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Patch formation following transplantation of different lung cell doses. (A): Typical histological sections showing GFP+ patches (circled) after transplantation of 1E + 6 or 8E + 6 adult lung cells following host conditioning (scale bar = 200 µm). (B): Average number of GFP+ patches in 2 × 2 × 1 mm³ lung area of recipient mice (n = 4 mice per each group). Errors bars represent mean ± SD. t test was used in order to analyze statistical significance between the E16 group and all the others. (C): Linear regression of the average number of patches as a function of cell dose. The frequency of patch forming cells in adult lung cells was calculated from the slope of the line as indicated. Errors bars represent mean ± SD. ANOVA and Dunnett's test were used to analyze statistical significance between the E16 group and all the other groups. *, p < .05; **, p < .01; ***, p < .001. Abbreviation: ANOVA, analysis of variance.