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. 2017 Nov 22;7(1):59–67. doi: 10.1002/sctm.17-0187

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© 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Intravitreal delivery of low dose ECFCs demonstrates therapeutic efficacy comparable to higher cell doses in the murine oxygen induced retinopathy model. (A): Representative fluorescein angiographs acquired in post‐natal day 17 (P17) mice demonstrating the retinal vasculature in vivo. Avascular areas are highlighted with an asterisk. Scale bars = 1 mm. (B): Representative flat‐mounted retinas (magnification ×4) from P17 mice stained with isolectin B4 (Alexa488) to identify the retinal vasculature. Avascular areas are delineated in white. (C): Quantification of avascular area expressed as a percentage of total retina area. Figure shows individual data points with mean, interquartiles, and range. *, p < .05; ***, p < .001, ns: not significant. One‐way ANOVA with Bonferroni's post‐test. Figure shows statistical significance compared to vehicle treated retinas. Abbreviations: ECFCs, endothelial colony‐forming cells; P12, post‐natal day 12.