Figure 6.

RAS Pathway Activation Is Associated with PD-L1 Upregulation in Human Cancers

(A) Heat-maps showing fold change in expression of T cell function related genes between high and low RAS pathway activity cohorts of lung adenocarcinoma (LUAD) and colon adenocarcinoma (COAD) TCGA samples. KRAS mutation status (codons 12, 13, and 61) is indicated for each sample. Genes are ranked in order of significance. Wald test, DESeq2.

(B) Box-and-whisker plots comparing PD-L1 mRNA expression in RAS high versus low pathway activity cohorts in LUAD and COAD using two independent RAS gene expression signatures. Wald test, DESeq2.

See also Figure S6.